-transparent.png){kind=logo}
The effect of volatile anesthetics on protein synthesis and secretion by isolated rat hepatocytes in suspension was investigated. Halothane and enflurane inhibited protein synthesis in a dose-dependent manner. Diethyl ether had little effect on protein synthesis while isoflurane caused a mild inhibition. This effect was more pronounced in hepatocytes from phenobarbital treated male rats when compared to hepatocytes from control rats. Protein synthesis in hepatocytes from phenobarbital treated female rats was inhibited similar to that seen with control male rat hepatocytes. Isoflurane, enflurane, and halothane also caused a dose-dependent inhibition of protein secretion, while diethyl ether was only mildly inhibitory. From these studies it appears that inhibition of protein synthesis and secretion might be an early and sensitive indicator of cellular injury by volatile anesthetics.
A B DiRenzo, and
C R Adamson, and
A J Gandolfi, and
K Brendel, and
G Krack
January 1985,
Drug and chemical toxicology,
A B DiRenzo, and
C R Adamson, and
A J Gandolfi, and
K Brendel, and
G Krack
November 1977,
Biochimica et biophysica acta,
A B DiRenzo, and
C R Adamson, and
A J Gandolfi, and
K Brendel, and
G Krack
January 1991,
Advances in experimental medicine and biology,
A B DiRenzo, and
C R Adamson, and
A J Gandolfi, and
K Brendel, and
G Krack
July 1994,
Hepatology (Baltimore, Md.),
A B DiRenzo, and
C R Adamson, and
A J Gandolfi, and
K Brendel, and
G Krack
April 1997,
British journal of pharmacology,
A B DiRenzo, and
C R Adamson, and
A J Gandolfi, and
K Brendel, and
G Krack
January 1990,
Archives of toxicology,
A B DiRenzo, and
C R Adamson, and
A J Gandolfi, and
K Brendel, and
G Krack
December 1956,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
A B DiRenzo, and
C R Adamson, and
A J Gandolfi, and
K Brendel, and
G Krack
October 1989,
Anesthesiology,
A B DiRenzo, and
C R Adamson, and
A J Gandolfi, and
K Brendel, and
G Krack
December 1979,
Biochimica et biophysica acta,
A B DiRenzo, and
C R Adamson, and
A J Gandolfi, and
K Brendel, and
G Krack
January 1975,
The Biochemical journal,
