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Ascites from patients with metastatic ovarian carcinoma contains high amounts of an activity that increases vascular permeability, as easily detected by a rat skin test. Ascites was fractionated by gel permeation and reversed-phase high-performance liquid chromatographies. The fractions were analysed for permeability-increasing activity. In this way a peptide was isolated and identified as Ile-Ser-bradykinin by sequence and amino-acid analyses. It is identical with T-kinin which has previously been detected as a product of an acute-phase protein, T-kininogen, in rats but never in human material. The so far identified human kininogens, i.e. high- and low-molecular mass kininogens, can only release Met-Lys-bradykinin or its degradations products, as Ile-Ser-bradykinin is not a part of their structure. However, the present results provide evidence that the permeability factor Ile-Ser-bradykinin under certain conditions can be produced in considerable amounts also by human tissues.
G Wunderer, and
I Walter, and
E Müller, and
A Henschen
July 1987,
FEBS letters,
G Wunderer, and
I Walter, and
E Müller, and
A Henschen
January 1992,
Agents and actions. Supplements,
G Wunderer, and
I Walter, and
E Müller, and
A Henschen
January 1991,
Biochemical pharmacology,
G Wunderer, and
I Walter, and
E Müller, and
A Henschen
January 1989,
Advances in experimental medicine and biology,
G Wunderer, and
I Walter, and
E Müller, and
A Henschen
January 1992,
Agents and actions. Supplements,
G Wunderer, and
I Walter, and
E Müller, and
A Henschen
September 1990,
The Journal of pharmacology and experimental therapeutics,
G Wunderer, and
I Walter, and
E Müller, and
A Henschen
May 1996,
Immunopharmacology,
G Wunderer, and
I Walter, and
E Müller, and
A Henschen
April 1994,
Biochemical pharmacology,
G Wunderer, and
I Walter, and
E Müller, and
A Henschen
September 1983,
Biochemical pharmacology,
G Wunderer, and
I Walter, and
E Müller, and
A Henschen
October 1985,
FEBS letters,
