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The conversion of testosterone into 5 alpha-dihydrotestosterone (DHT) has been studied in different hypothalamic nuclear areas and in the superficial layers of the cerebral cortex of normal and castrated male rats. The tissue fragments utilized in each incubation have been punched from frozen brain sections utilizing calibrated needles. Castration has been performed 12 (short term) and 180 (long term) days before sacrifice. The nuclear areas studied include: the medial preoptic nucleus (MPN), the lateral preoptic nucleus (LPN), the anterior hypothalamic nucleus (AHN), the lateral hypothalamic nucleus (LHN), the posterior hypothalamic nucleus (PHN), the nucleus ventromedialis (HVM), the arcuate nucleus (AR), the median eminence (ME), the nucleus paraventricularis (HPV), the supraoptic nucleus (SO) and the suprachiasmatic nucleus (SC). The possible effect of castration on the 5 alpha-reductase, were assessed in the MPN,LPN,AHN,LHN,PHN and in the cerebral cortex. The results indicate that, in the male rat: 1) the lateral preoptic(LPN) and the lateral hypothalamic nuclei(LHN) possess a 5 alpha-reductase activity higher than that present in the cerebral cortex and in the other hypothalamic nuclei considered; 2)the suprachiasmatic nucleus (SC) apparently possesses a testosterone metabolizing activity lower than that found in any other nervous structures studied so far; 3) castration does not seem to influence the 5 alpha-reductase activity either in the hypothalamic nuclear structures considered or in the cerebral cortex.
R C Melcangi, and
F Celotti, and
P Negri-Cesi, and
L Martini
May 1983,
Journal of neurochemistry,
R C Melcangi, and
F Celotti, and
P Negri-Cesi, and
L Martini
October 1973,
Endocrinologia japonica,
R C Melcangi, and
F Celotti, and
P Negri-Cesi, and
L Martini
January 1983,
Hormone research,
R C Melcangi, and
F Celotti, and
P Negri-Cesi, and
L Martini
January 1974,
Biochimie,
R C Melcangi, and
F Celotti, and
P Negri-Cesi, and
L Martini
February 1974,
Biochemistry,
R C Melcangi, and
F Celotti, and
P Negri-Cesi, and
L Martini
December 1972,
Endocrinologia japonica,
R C Melcangi, and
F Celotti, and
P Negri-Cesi, and
L Martini
January 2002,
The Journal of steroid biochemistry and molecular biology,
R C Melcangi, and
F Celotti, and
P Negri-Cesi, and
L Martini
May 1981,
The Journal of pharmacology and experimental therapeutics,
R C Melcangi, and
F Celotti, and
P Negri-Cesi, and
L Martini
February 1982,
Brain research,
R C Melcangi, and
F Celotti, and
P Negri-Cesi, and
L Martini
July 1991,
Molecular endocrinology (Baltimore, Md.),
