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Whole ejaculates were examined for their content of prostaglandins (PGs) during medication with 250 mg naproxen three times daily for 2 weeks. Six volunteers delivered semen samples before, periodically during, and after the period of medication. During treatment with naproxen, the concentration of PGE, PGF, 19-hydroxy-PGE, and 19-hydroxy-PGF significantly decreased. One week after cessation of medication the PG concentration had returned almost to that found before treatment. The four 19-hydroxy-PGF compounds could be determined separately and the relation between them estimated. The proportion of 8 alpha-19-hydroxy-PGF2 alpha increased, whereas that of 8 beta-19-hydroxy-PGF1 alpha decreased significantly during the medication period. No significant influence of the treatment on sperm density or motility could be observed. It is concluded that treatment with naproxen, a potent inhibitor of PG synthesis, significantly reduces the concentration of all PGs present in human seminal fluid. The implication of the effect on human fertility is discussed.
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C Gottlieb, and
K Svanborg, and
M Bygdeman, and
P Eneroth, and
Q H Cai
February 1985,
International journal of andrology,
E Bendvold, and
C Gottlieb, and
K Svanborg, and
M Bygdeman, and
P Eneroth, and
Q H Cai
September 1982,
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E Bendvold, and
C Gottlieb, and
K Svanborg, and
M Bygdeman, and
P Eneroth, and
Q H Cai
October 1971,
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E Bendvold, and
C Gottlieb, and
K Svanborg, and
M Bygdeman, and
P Eneroth, and
Q H Cai
March 1975,
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E Bendvold, and
C Gottlieb, and
K Svanborg, and
M Bygdeman, and
P Eneroth, and
Q H Cai
January 1994,
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E Bendvold, and
C Gottlieb, and
K Svanborg, and
M Bygdeman, and
P Eneroth, and
Q H Cai
July 1977,
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E Bendvold, and
C Gottlieb, and
K Svanborg, and
M Bygdeman, and
P Eneroth, and
Q H Cai
January 1983,
Advances in prostaglandin, thromboxane, and leukotriene research,
E Bendvold, and
C Gottlieb, and
K Svanborg, and
M Bygdeman, and
P Eneroth, and
Q H Cai
May 1984,
Nihon Sanka Fujinka Gakkai zasshi,
E Bendvold, and
C Gottlieb, and
K Svanborg, and
M Bygdeman, and
P Eneroth, and
Q H Cai
February 1986,
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E Bendvold, and
C Gottlieb, and
K Svanborg, and
M Bygdeman, and
P Eneroth, and
Q H Cai
December 1969,
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