Biomaterial Database

Electron microscopic localization of N-terminal proenkephalin (synenkephalin) immunostaining in the guinea pig organ of Corti. 1985

M Eybalin, and L Abou-Madi, and J Rossier, and R Pujol

Using a pre-embedding immunoelectron microscopic technique, anti-synenkephalin immunostaining has been demonstrated within efferent varicosities (originating from the brainstem) of the inner spiral bundle and the tunnel spiral bundle of the organ of Corti. Axodendritic synapses were observed between the anti-synenkephalin immunostained varicosities and auditory dendrites connected to inner hair cells. No anti-synenkephalin immunostaining was found in any efferents at the outer hair cell level. We suggest that this immunolocalization of synenkephalin in the organ of Corti allows a better differentiation of the cochlear efferent systems on a neurochemical basis. The whole lateral system, or at least a significant part of it, could be referred to as the 'enkephalin-containing efferent system'.

UI	MeSH Term	Description	Entries
D007120	Immunochemistry	Field of chemistry that pertains to immunological phenomena and the study of chemical reactions related to antigen stimulation of tissues. It includes physicochemical interactions between antigens and antibodies.
D008854	Microscopy, Electron	Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.	Electron Microscopy
D009925	Organ of Corti	The spiral EPITHELIUM containing sensory AUDITORY HAIR CELLS and supporting cells in the cochlea. Organ of Corti, situated on the BASILAR MEMBRANE and overlaid by a gelatinous TECTORIAL MEMBRANE, converts sound-induced mechanical waves to neural impulses to the brain.	Basilar Papilla,Corti's Organ,Spiral Organ,Corti Organ,Cortis Organ,Organ, Corti's,Organ, Spiral,Organs, Spiral,Papilla, Basilar,Spiral Organs
D011498	Protein Precursors		Precursors, Protein
D004745	Enkephalins	One of the three major families of endogenous opioid peptides. The enkephalins are pentapeptides that are widespread in the central and peripheral nervous systems and in the adrenal medulla.	Enkephalin
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D006651	Histocytochemistry	Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.	Cytochemistry
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia

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