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The effect of pretreatment with the noradrenaline neurotoxin, N-2-chloroethyl-N-ethyl-2-bromobenzylamine (DSP4), upon the analgesia induced by various doses of 5-hydroxytryptamine (5-HT) was examined in rats and mice. DSP4 treatment (2 X 50 mg/kg, intraperitoneally) of rats caused a complete blockade of 5-HT induced analgesia in the tail-flick, hot-plate and shock titration tests. DSP4 treatment (1 X 50 mg/kg, intraperitoneally) of mice caused a partial blockade of 5-HT induced analgesia in the hot-plate test, but no significant blockade in the tail-flick test. These results are discussed with regard to serotonergic-noradrenergic interactions and the species discrepancy in nociceptive testing.
T Archer, and
E Arweström, and
G Jonsson, and
B G Minor, and
C Post
February 1985,
Neuroscience letters,
T Archer, and
E Arweström, and
G Jonsson, and
B G Minor, and
C Post
April 1985,
Brain research,
T Archer, and
E Arweström, and
G Jonsson, and
B G Minor, and
C Post
January 1986,
Brain research,
T Archer, and
E Arweström, and
G Jonsson, and
B G Minor, and
C Post
March 1971,
Biochemical pharmacology,
T Archer, and
E Arweström, and
G Jonsson, and
B G Minor, and
C Post
October 1979,
Archives internationales de pharmacodynamie et de therapie,
T Archer, and
E Arweström, and
G Jonsson, and
B G Minor, and
C Post
March 1987,
Acta physiologica Scandinavica,
T Archer, and
E Arweström, and
G Jonsson, and
B G Minor, and
C Post
October 1979,
Archives internationales de pharmacodynamie et de therapie,
T Archer, and
E Arweström, and
G Jonsson, and
B G Minor, and
C Post
April 1998,
European journal of pharmacology,
T Archer, and
E Arweström, and
G Jonsson, and
B G Minor, and
C Post
July 1980,
Neuropharmacology,
T Archer, and
E Arweström, and
G Jonsson, and
B G Minor, and
C Post
October 1976,
The Journal of pharmacy and pharmacology,
