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Second remission induction rates for vincristine and prednisone alone (VP) and vincristine, L-asparaginase, and prednisone (VLP) are compared for children with acute lymphocytic leukemia. No evidence of a significant difference between the second induction complete remission rate for VP (78.6%) and VLP (73.7%) was found. Duration of first remission and prognostic group at initial diagnosis (defined on the basis of age and white blood count at initial diagnosis) are shown to be significant prognostic factors for second remission induction; and three second remission induction risk groups are defined on the basis of these two factors. Periodic reinforcement with prednisone in first remission does not appear to lower second induction complete response (CR) rates for VP. There was no evidence of a significant difference in the frequency of occurrence of severe toxicity between the VP and VLP regimens.
J Herson, and
K A Starling, and
P G Dyment, and
G B Humphrey, and
J Pullen, and
T Vats
February 1977,
Cancer research,
J Herson, and
K A Starling, and
P G Dyment, and
G B Humphrey, and
J Pullen, and
T Vats
January 1976,
Medical and pediatric oncology,
J Herson, and
K A Starling, and
P G Dyment, and
G B Humphrey, and
J Pullen, and
T Vats
February 1978,
Cancer,
J Herson, and
K A Starling, and
P G Dyment, and
G B Humphrey, and
J Pullen, and
T Vats
March 1976,
Cancer,
J Herson, and
K A Starling, and
P G Dyment, and
G B Humphrey, and
J Pullen, and
T Vats
January 1977,
Oncology,
J Herson, and
K A Starling, and
P G Dyment, and
G B Humphrey, and
J Pullen, and
T Vats
August 1976,
Cancer,
J Herson, and
K A Starling, and
P G Dyment, and
G B Humphrey, and
J Pullen, and
T Vats
June 1981,
Cancer,
J Herson, and
K A Starling, and
P G Dyment, and
G B Humphrey, and
J Pullen, and
T Vats
June 1976,
La Nouvelle presse medicale,
J Herson, and
K A Starling, and
P G Dyment, and
G B Humphrey, and
J Pullen, and
T Vats
June 2009,
Zhongguo shi yan xue ye xue za zhi,
J Herson, and
K A Starling, and
P G Dyment, and
G B Humphrey, and
J Pullen, and
T Vats
January 1979,
Medical and pediatric oncology,
