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Using strips of rat pregnant uterus, treated with indomethacin to suppress spontaneous contractility, the oxytocic activity of prostacyclin was compared with other prostaglandins. A prostacyclin concentration of 32 ng/ml elicited uterine contractions in all experiments. In this respect prostacyclin was 80 times more active than 6-oxo-PGF1 alpha but less active than PGE2 or PGF2 alpha. Apart from a direct stimulant effect, prostacyclin also exhibited an indirect potentiating action. In threshold concentrations prostacyclin caused a 3-fold potentiation of threshold doses of oxytocin. A lesser 1.5-fold potentiation of PGE2 alpha was also observed. The implications of these findings in relation to prostacyclin playing a role in parturition are discussed.
K I Williams, and
K E El-Tahir, and
E Marcinkiewicz
January 1979,
Prostaglandins,
K I Williams, and
K E El-Tahir, and
E Marcinkiewicz
September 1979,
Archives internationales de pharmacodynamie et de therapie,
K I Williams, and
K E El-Tahir, and
E Marcinkiewicz
February 1979,
Prostaglandins,
K I Williams, and
K E El-Tahir, and
E Marcinkiewicz
January 1978,
Acta biologica et medica Germanica,
K I Williams, and
K E El-Tahir, and
E Marcinkiewicz
February 1978,
Prostaglandins,
K I Williams, and
K E El-Tahir, and
E Marcinkiewicz
January 1983,
Intensive care medicine,
K I Williams, and
K E El-Tahir, and
E Marcinkiewicz
April 1979,
Prostaglandins,
K I Williams, and
K E El-Tahir, and
E Marcinkiewicz
July 1963,
Indian journal of physiology and pharmacology,
K I Williams, and
K E El-Tahir, and
E Marcinkiewicz
June 1978,
Prostaglandins,
K I Williams, and
K E El-Tahir, and
E Marcinkiewicz
April 1985,
Prostaglandins, leukotrienes, and medicine,
