-transparent.png){kind=logo}
The effects of intraventricularly administered prostaglandins I2 (PGI2), E2 (PGE2), F2alpha (PGF2 alpha) and indomethacin on systemic blood pressure were investigated in conscious rats. PGI2 (1.25--10 micrograms/kg) decreased blood pressure in a dose-related manner, whereas PGE2 (100--1000 mg/kg) dose-dependently increased blood pressure. Both PGF2 alpha (0.31--20 micrograms/kg) and indomethacin (0.625--40 micrograms/kg) had no effects on blood pressure. These results indicate that intraventricular injection of PGI2 or PGE2 can induce significant changes in blood pressure, while endogenous prostaglandins synthesized in the brain seem to play a minor role in direct regulation of systemic blood pressure in the rat.
K Kondo, and
T Okuno, and
T Saruta, and
E Kato
January 1983,
Psychopharmacology,
K Kondo, and
T Okuno, and
T Saruta, and
E Kato
July 1982,
Agents and actions,
K Kondo, and
T Okuno, and
T Saruta, and
E Kato
February 1981,
British journal of urology,
K Kondo, and
T Okuno, and
T Saruta, and
E Kato
January 1983,
Advances in prostaglandin, thromboxane, and leukotriene research,
K Kondo, and
T Okuno, and
T Saruta, and
E Kato
September 1988,
Japanese journal of pharmacology,
K Kondo, and
T Okuno, and
T Saruta, and
E Kato
June 1982,
Canadian journal of physiology and pharmacology,
K Kondo, and
T Okuno, and
T Saruta, and
E Kato
January 1981,
Experientia,
K Kondo, and
T Okuno, and
T Saruta, and
E Kato
June 1982,
Prostaglandins, leukotrienes, and medicine,
K Kondo, and
T Okuno, and
T Saruta, and
E Kato
December 1981,
Prostaglandins,
K Kondo, and
T Okuno, and
T Saruta, and
E Kato
March 1986,
Biochemical and biophysical research communications,
