Conformational changes induced by selected flavor compounds from spices regulate the binding ability of myofibrillar proteins to aldehyde compounds. 2024

Xiangxiang Sun, and Yumei Yu, and Ahmed S M Saleh, and Kumayl Hassan Akhtar, and Wenhao Li, and Dequan Zhang, and Zhenyu Wang
Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China; Integrated Laboratory of Processing Technology for Chinese Meat and Dish Products, Ministry of Agriculture and Rural Affairs, Beijing 100193, China; College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China.

Interactions among flavor compounds from spices (FCS) and myofibrillar proteins (MP) were investigated. Fluorescence and Fourier transform infrared spectroscopy showed that hydrogen bonding and hydrophobic interactions were the main binding forces between FCS and MP. The FCS increased the particle size and SH content of MP and caused a reduction of zeta potential from -5.23 to -6.50 mV. Furthermore, FCS could modify the binding ability of MP and aldehydes. Eugenol reduced the ability of MP to bond with aldehydes by 22.70-47.87 %. Molecular dynamics simulations demonstrated that eugenol may combat nonanal to attain binding site of amino acid residue (PHE165) and induce protein conformational changes. Electrostatic interactions and van der Waals forces within myosin-nonanal may be disrupted by these alterations, which could reduce stability of complex and cause release of nonanal. This study could provide new insights into regulating the ability of proteins to release and hold flavors.

UI MeSH Term Description Entries
D009124 Muscle Proteins The protein constituents of muscle, the major ones being ACTINS and MYOSINS. More than a dozen accessory proteins exist including TROPONIN; TROPOMYOSIN; and DYSTROPHIN. Muscle Protein,Protein, Muscle,Proteins, Muscle
D009210 Myofibrils The long cylindrical contractile organelles of STRIATED MUSCLE cells composed of ACTIN FILAMENTS; MYOSIN filaments; and other proteins organized in arrays of repeating units called SARCOMERES . Myofilaments,Myofibril,Myofilament
D011485 Protein Binding The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments. Plasma Protein Binding Capacity,Binding, Protein
D011487 Protein Conformation The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain). Conformation, Protein,Conformations, Protein,Protein Conformations
D005421 Flavoring Agents Substances added to foods and medicine to improve the taste. Flavor Additives,Flavor Enhancers,Additive, Flavor,Additives, Flavor,Agent, Flavoring,Agents, Flavoring,Enhancer, Flavor,Enhancers, Flavor,Flavor Additive,Flavor Enhancer,Flavoring Agent
D006860 Hydrogen Bonding A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds. Hydrogen Bonds,Bond, Hydrogen,Hydrogen Bond
D000447 Aldehydes Organic compounds containing a carbonyl group in the form -CHO. Aldehyde
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D017365 Spices The dried seeds, bark, root, stems, buds, leaves, or fruit of aromatic plants used to season food. Spice
D056004 Molecular Dynamics Simulation A computer simulation developed to study the motion of molecules over a period of time. Molecular Dynamics Simulations,Molecular Dynamics,Dynamic, Molecular,Dynamics Simulation, Molecular,Dynamics Simulations, Molecular,Dynamics, Molecular,Molecular Dynamic,Simulation, Molecular Dynamics,Simulations, Molecular Dynamics

Related Publications

Xiangxiang Sun, and Yumei Yu, and Ahmed S M Saleh, and Kumayl Hassan Akhtar, and Wenhao Li, and Dequan Zhang, and Zhenyu Wang
August 2019, Journal of the science of food and agriculture,
Xiangxiang Sun, and Yumei Yu, and Ahmed S M Saleh, and Kumayl Hassan Akhtar, and Wenhao Li, and Dequan Zhang, and Zhenyu Wang
March 2022, Foods (Basel, Switzerland),
Xiangxiang Sun, and Yumei Yu, and Ahmed S M Saleh, and Kumayl Hassan Akhtar, and Wenhao Li, and Dequan Zhang, and Zhenyu Wang
November 2023, Journal of agricultural and food chemistry,
Xiangxiang Sun, and Yumei Yu, and Ahmed S M Saleh, and Kumayl Hassan Akhtar, and Wenhao Li, and Dequan Zhang, and Zhenyu Wang
May 2005, Journal of agricultural and food chemistry,
Xiangxiang Sun, and Yumei Yu, and Ahmed S M Saleh, and Kumayl Hassan Akhtar, and Wenhao Li, and Dequan Zhang, and Zhenyu Wang
October 2014, Journal of agricultural and food chemistry,
Xiangxiang Sun, and Yumei Yu, and Ahmed S M Saleh, and Kumayl Hassan Akhtar, and Wenhao Li, and Dequan Zhang, and Zhenyu Wang
October 2004, The Journal of biological chemistry,
Xiangxiang Sun, and Yumei Yu, and Ahmed S M Saleh, and Kumayl Hassan Akhtar, and Wenhao Li, and Dequan Zhang, and Zhenyu Wang
September 1991, The Journal of membrane biology,
Xiangxiang Sun, and Yumei Yu, and Ahmed S M Saleh, and Kumayl Hassan Akhtar, and Wenhao Li, and Dequan Zhang, and Zhenyu Wang
April 1995, Bioorganic & medicinal chemistry,
Xiangxiang Sun, and Yumei Yu, and Ahmed S M Saleh, and Kumayl Hassan Akhtar, and Wenhao Li, and Dequan Zhang, and Zhenyu Wang
March 2006, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
Xiangxiang Sun, and Yumei Yu, and Ahmed S M Saleh, and Kumayl Hassan Akhtar, and Wenhao Li, and Dequan Zhang, and Zhenyu Wang
August 2008, Journal of bioinformatics and computational biology,
Copied contents to your clipboard!