-transparent.png){kind=logo}
Cross-reactive anti-DNA antibody idiotypes have been identified on tissue-bound immunoglobulins from skin biopsies of patients with systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE). Four polyclonal and two monoclonal anti-idiotypic reagents were used to screen biopsies from 24 patients with SLE, 23 patients with DLE, and 15 other patients with IgM-positive skin biopsies. Up to 46% of the SLE patients and 30% of the DLE patients were found to share idiotypes present on immunoglobulins deposited at the dermal-epidermal junction. Inhibition studies in four patients indicated that the idiotypes were on anti-DNA antibodies. In contrast, none of the anti-idiotypic antibodies bound to any of the control biopsies. These findings imply that some tissue-bound autoantibodies are derived from related families of high-frequency germ-line genes that are expressed in both SLE and DLE.
D Isenberg, and
C Dudeney, and
F Wojnaruska, and
B S Bhogal, and
J Rauch, and
A Schattner, and
Y Naparstek, and
D Duggan
July 1985,
The Journal of clinical investigation,
D Isenberg, and
C Dudeney, and
F Wojnaruska, and
B S Bhogal, and
J Rauch, and
A Schattner, and
Y Naparstek, and
D Duggan
August 1991,
Clinical and experimental immunology,
D Isenberg, and
C Dudeney, and
F Wojnaruska, and
B S Bhogal, and
J Rauch, and
A Schattner, and
Y Naparstek, and
D Duggan
June 1986,
Clinical immunology and immunopathology,
D Isenberg, and
C Dudeney, and
F Wojnaruska, and
B S Bhogal, and
J Rauch, and
A Schattner, and
Y Naparstek, and
D Duggan
March 1984,
Journal of immunology (Baltimore, Md. : 1950),
D Isenberg, and
C Dudeney, and
F Wojnaruska, and
B S Bhogal, and
J Rauch, and
A Schattner, and
Y Naparstek, and
D Duggan
August 1984,
Lancet (London, England),
D Isenberg, and
C Dudeney, and
F Wojnaruska, and
B S Bhogal, and
J Rauch, and
A Schattner, and
Y Naparstek, and
D Duggan
May 1992,
Clinical immunology and immunopathology,
D Isenberg, and
C Dudeney, and
F Wojnaruska, and
B S Bhogal, and
J Rauch, and
A Schattner, and
Y Naparstek, and
D Duggan
December 1994,
Harefuah,
D Isenberg, and
C Dudeney, and
F Wojnaruska, and
B S Bhogal, and
J Rauch, and
A Schattner, and
Y Naparstek, and
D Duggan
February 2001,
Scandinavian journal of immunology,
D Isenberg, and
C Dudeney, and
F Wojnaruska, and
B S Bhogal, and
J Rauch, and
A Schattner, and
Y Naparstek, and
D Duggan
May 1987,
Clinical immunology and immunopathology,
D Isenberg, and
C Dudeney, and
F Wojnaruska, and
B S Bhogal, and
J Rauch, and
A Schattner, and
Y Naparstek, and
D Duggan
October 1983,
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
