Biomaterial Database

Effect of heat on radiosensitivity at different developmental stages of embryos of the fish Oryzias latipes. 1985

Y Shimada, and N Egami, and A Shima

Embryos of the fish, Oryzias latipes, at various developmental stages were heated before or after gamma-irradiation. The lethal effects of heat and radiation treatments were determined by the hatchability of the irradiated embryos. The radiosensitivity suddenly decreased at 3-days after fertilization. Heat (41 degrees C), either preceding or following irradiation, decreased the shoulder region (Dq) of the dose-response curves of the embryos irradiated at the 1-3 day stages, and increased the slope (D0) only at the 3 day stage. The magnitude of enhancement of radiosensitivity by pre- and post-heating was found to depend on the time and temperature of the heat as well as the developmental stage of the embryos; in 1- and 2-day embryos the effectiveness of post-irradiation heating was larger than that of pre-irradiation heating whereas in 3-day embryos there was no difference between the effectiveness of pre- and post-treatment. The sequence of heat (41 degrees C) and radiation treatment, and the time interval between the two treatments, also influenced the effectiveness of heat on radiosensitivity, depending upon the developmental stage; recovery from heat effects was not observed within a time interval of up to 3 h before radiation exposure for either 1- or 3-day embryos, whereas recovery from the radiation lesion occurred, for only 1-day embryos, within 1 h of subsequent heat exposure.

UI	MeSH Term	Description	Entries
D011836	Radiation Tolerance	The ability of some cells or tissues to survive lethal doses of IONIZING RADIATION. Tolerance depends on the species, cell type, and physical and chemical variables, including RADIATION-PROTECTIVE AGENTS and RADIATION-SENSITIZING AGENTS.	Radiation Sensitivity,Radiosensitivity,Sensitivity, Radiation,Tolerance, Radiation,Radiation Sensitivities,Radiation Tolerances,Radiosensitivities,Sensitivities, Radiation,Tolerances, Radiation
D004625	Embryo, Nonmammalian	The developmental entity of a fertilized egg (ZYGOTE) in animal species other than MAMMALS. For chickens, use CHICK EMBRYO.	Embryonic Structures, Nonmammalian,Embryo, Non-Mammalian,Embryonic Structures, Non-Mammalian,Nonmammalian Embryo,Nonmammalian Embryo Structures,Nonmammalian Embryonic Structures,Embryo Structure, Nonmammalian,Embryo Structures, Nonmammalian,Embryo, Non Mammalian,Embryonic Structure, Non-Mammalian,Embryonic Structure, Nonmammalian,Embryonic Structures, Non Mammalian,Embryos, Non-Mammalian,Embryos, Nonmammalian,Non-Mammalian Embryo,Non-Mammalian Embryonic Structure,Non-Mammalian Embryonic Structures,Non-Mammalian Embryos,Nonmammalian Embryo Structure,Nonmammalian Embryonic Structure,Nonmammalian Embryos,Structure, Non-Mammalian Embryonic,Structure, Nonmammalian Embryo,Structure, Nonmammalian Embryonic,Structures, Non-Mammalian Embryonic,Structures, Nonmammalian Embryo,Structures, Nonmammalian Embryonic
D005399	Fishes	A group of cold-blooded, aquatic vertebrates having gills, fins, a cartilaginous or bony endoskeleton, and elongated bodies covered with scales.
D006358	Hot Temperature	Presence of warmth or heat or a temperature notably higher than an accustomed norm.	Heat,Hot Temperatures,Temperature, Hot,Temperatures, Hot
D000367	Age Factors	Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.	Age Reporting,Age Factor,Factor, Age,Factors, Age
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor