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The antifungal activity of three antibiotics of the iturin group: iturin A, mycosubtilin, bacillomycin L and of eleven methylated and acetylated derivatives of these antibiotics was tested upon Saccharomyces cerevisiae. The lowest MIC values were found for natural antibiotics. The substitution of polar groups diminished the antifungal activity. Various lipids, sterols, fatty acids, fatty acid methyl esters and phospholipids were tested as inhibitors of the antifungal activity of iturin A, mycosubtilin and bacillomycin L. Cholesterol was the strongest inhibitor upon the three antibiotics; ergosterol, oleic acid and cis-vaccenic acid were less potent inhibitors. Among phospholipids, phosphatidyl choline inhibited bacillomycin L and iturin A while diphosphatidyl glycerol inhibited bacillomycin L and mycosubtilin. The inhibitory effect appeared to be dependent on the nature of both the hydrophilic group and the fatty acid part of phospholipids.
F Besson, and
F Peypoux, and
G Michel, and
L Delcambe
April 2001,
Journal of applied microbiology,
F Besson, and
F Peypoux, and
G Michel, and
L Delcambe
January 1991,
Microbios,
F Besson, and
F Peypoux, and
G Michel, and
L Delcambe
January 1989,
Microbios,
F Besson, and
F Peypoux, and
G Michel, and
L Delcambe
November 1987,
The Journal of antibiotics,
F Besson, and
F Peypoux, and
G Michel, and
L Delcambe
November 1995,
The Journal of antibiotics,
F Besson, and
F Peypoux, and
G Michel, and
L Delcambe
October 2002,
Molecular microbiology,
F Besson, and
F Peypoux, and
G Michel, and
L Delcambe
January 2018,
Frontiers in microbiology,
F Besson, and
F Peypoux, and
G Michel, and
L Delcambe
November 1988,
The Journal of antibiotics,
F Besson, and
F Peypoux, and
G Michel, and
L Delcambe
April 1997,
The Journal of biological chemistry,
F Besson, and
F Peypoux, and
G Michel, and
L Delcambe
March 1988,
Biochimica et biophysica acta,
