-transparent.png){kind=logo}
Attempts were made to examine strain differences in the susceptibility of rats to intestinal metaplasia induced by X-irradiation. The gastric regions of 4 inbred male rats (SHR, F344, WKY, and LEW strains) in 5-week-old and 2 random bred male rats (SD, and WIS strains) were irradiated with a total dose of 20 Gy X-ray given in two equal fractions separated by three days. Upon sacrifice at 6 months after the last irradiation, the number of intestinal metaplastic crypts with positive reaction to alkaline phosphatase (ALP) appeared highest in the SHR and lowest in the WIS rats. Morphologically, the number of crypts with intestinal metaplasia in whole glandular stomachs of SHR, WIS, F344, and SD rats were higher than those in WKY and LEW rats. In the pyloric gland, it was highest in WIS rats, while in the fundic gland it was highest in SHR rats. The results show that the appearance and location of intestinal metaplasia by X-irradiation are greatly influenced by the strain of the rat.
H Watanabe, and
M Naito, and
K Kawashima, and
A Ito
November 1978,
Gastroenterology,
H Watanabe, and
M Naito, and
K Kawashima, and
A Ito
October 1988,
Acta pathologica japonica,
H Watanabe, and
M Naito, and
K Kawashima, and
A Ito
October 1993,
Japanese journal of cancer research : Gann,
H Watanabe, and
M Naito, and
K Kawashima, and
A Ito
June 1997,
Journal of gastroenterology,
H Watanabe, and
M Naito, and
K Kawashima, and
A Ito
September 1993,
Acta pathologica japonica,
H Watanabe, and
M Naito, and
K Kawashima, and
A Ito
November 1999,
Japanese journal of cancer research : Gann,
H Watanabe, and
M Naito, and
K Kawashima, and
A Ito
November 2000,
Pathology international,
H Watanabe, and
M Naito, and
K Kawashima, and
A Ito
May 1996,
Japanese journal of cancer research : Gann,
H Watanabe, and
M Naito, and
K Kawashima, and
A Ito
January 1998,
Oncology reports,
H Watanabe, and
M Naito, and
K Kawashima, and
A Ito
December 1980,
Pathology, research and practice,
