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Effects of azoxymethane on X-ray induced intestinal metaplasia in Donryu rats. 1998
H Watanabe, and
N Fujimoto, and
Y Masaoka, and
M Kurosumi, and
T Oguri, and
T Takahashi, and
S Kido, and
S Hirata, and
K Kuramoto, and
S Shoji, and
O Katoh
Department of Environment and Mutation, Research Institute for Radiation Biology and Medicine, Hiroshima University, Minami-ku, Hiroshima, 734-8553, Japan.
The present study was undertaken to determine the effect of azoxymethane (AOM) administration on intestinal metaplasia induced by X-irradiation in male Donryu rats. Five-week-old animals were X-irradiated with two doses of 10 Gy each at a 3-day interval or three X-ray doses of 10 Gy at a 2-day interval and then received AOM injections i.m. at a dose of 15 mg/kg body weight once weekly for 3 weeks, 6 months after irradiation. Alkaline phosphatase positive foci were decreased after AOM treatments, but aberrant crypt like-foci appeared within areas of intestinal metaplasia. In contrast no induction was observed in normal-appearing gastric mucosa.
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