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Effects of once-daily doses of 50 mg triamterene with 25 mg hydrochlorothiazide and 5 mg amiloride with 50 mg hydrochlorothiazide were compared in a randomized, multicenter study of 84 adult subjects with mild to moderate hypertension (diastolic blood pressure 90 to 114 mm Hg). After a 3-wk placebo lead-in period, the subjects entered a 6-wk treatment period. The two drug regimens were compared with respect to antihypertensive effects and effects on serum potassium and magnesium levels during the final week of drug therapy, with the use of the last week of placebo therapy as a covariate. Both drug regimens substantially reduced mean supine systolic and diastolic blood pressures to well within normal limits; there was no significant difference the two groups. Twenty-four of the 41 subjects receiving triamterene-hydrochlorothiazide (59%) and 29 of the 43 patients receiving amiloride-hydrochlorothiazide (67%) had diastolic blood pressure less than 90 mm Hg at week 9. Five subjects receiving amiloride-hydrochlorothiazide (12%) and two subjects receiving triamterene-hydrochlorothiazide (5%) had hypokalemia (serum potassium level less than 3.5 mEq/l) at week 9. The average decrease in serum potassium levels during amiloride-hydrochlorothiazide therapy (-0.33 +/- 0.08 mEq/l) was greater than that after triamterene-hydrochlorothiazide (- 0.08 +/- 0.07 mEq/l). Serum magnesium levels were not changed by either regimen. Weight loss was greater in the amiloride-hydrochlorothiazide group than in the triamterene-hydrochlorothiazide group.(ABSTRACT TRUNCATED AT 250 WORDS)
M H Maxwell, and
J Brachfeld, and
H Itskovitz, and
J A Lunn, and
M Moser, and
E T Zawada
January 2016,
Journal of general internal medicine,
M H Maxwell, and
J Brachfeld, and
H Itskovitz, and
J A Lunn, and
M Moser, and
E T Zawada
April 1985,
Canadian Medical Association journal,
M H Maxwell, and
J Brachfeld, and
H Itskovitz, and
J A Lunn, and
M Moser, and
E T Zawada
January 1982,
Current medical research and opinion,
M H Maxwell, and
J Brachfeld, and
H Itskovitz, and
J A Lunn, and
M Moser, and
E T Zawada
September 1990,
Klinicheskaia meditsina,
M H Maxwell, and
J Brachfeld, and
H Itskovitz, and
J A Lunn, and
M Moser, and
E T Zawada
January 1990,
Sovetskaia meditsina,
M H Maxwell, and
J Brachfeld, and
H Itskovitz, and
J A Lunn, and
M Moser, and
E T Zawada
January 1985,
Acta medica Scandinavica,
M H Maxwell, and
J Brachfeld, and
H Itskovitz, and
J A Lunn, and
M Moser, and
E T Zawada
October 2008,
Clinical and experimental hypertension (New York, N.Y. : 1993),
M H Maxwell, and
J Brachfeld, and
H Itskovitz, and
J A Lunn, and
M Moser, and
E T Zawada
January 1978,
Coeur et medecine interne,
M H Maxwell, and
J Brachfeld, and
H Itskovitz, and
J A Lunn, and
M Moser, and
E T Zawada
January 1976,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
M H Maxwell, and
J Brachfeld, and
H Itskovitz, and
J A Lunn, and
M Moser, and
E T Zawada
April 1972,
Drug and therapeutics bulletin,
