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A double-blind study was carried out in 24 hypertensive patients with thiazide-induced hypokalaemia (serum potassium less than 3.2 mmol/l) to compare the effects of treatment with an amiloride/hydrochlorothiazide combination or hydrochlorothiazide alone. The study was divided into three phases: (i) potassium repletion (Weeks 0 to 4) with oral potassium chloride (40 mmol/day), (ii) stabilization (Weeks 4 to 6) of normokalaemia, and (iii) active drug treatment (Weeks 6 to 14), patients being allocated at random to receive one or other of the two treatments. Dosage was 2 tablets per day of the 5 mg amiloride plus 50 mg hydrochlorothiazide combination or of 50 mg hydrochlorothiazide alone. The results showed that blood pressure control was comparable in both treatment groups but hydrochlorothiazide alone caused a statistically significant reduction in serum potassium levels compared to the drug combination. Apart from 1 patient who developed hypokalaemia on hydrochlorothiazide alone, no other side-effects of treatment were reported.
P G Fernandez, and
J N Sharma, and
A B Galway, and
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B K Kim, and
W Snedden, and
S Granter-Button, and
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January 1985,
Clinical pharmacology and therapeutics,
P G Fernandez, and
J N Sharma, and
A B Galway, and
N Campbell, and
B K Kim, and
W Snedden, and
S Granter-Button, and
J MacDonald, and
V Gill
December 1973,
Lancet (London, England),
P G Fernandez, and
J N Sharma, and
A B Galway, and
N Campbell, and
B K Kim, and
W Snedden, and
S Granter-Button, and
J MacDonald, and
V Gill
August 1984,
Clinical pharmacology and therapeutics,
P G Fernandez, and
J N Sharma, and
A B Galway, and
N Campbell, and
B K Kim, and
W Snedden, and
S Granter-Button, and
J MacDonald, and
V Gill
October 1984,
Clinical pharmacology and therapeutics,
P G Fernandez, and
J N Sharma, and
A B Galway, and
N Campbell, and
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W Snedden, and
S Granter-Button, and
J MacDonald, and
V Gill
January 1988,
Acta medica Scandinavica,
P G Fernandez, and
J N Sharma, and
A B Galway, and
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S Granter-Button, and
J MacDonald, and
V Gill
January 1985,
Acta medica Scandinavica,
P G Fernandez, and
J N Sharma, and
A B Galway, and
N Campbell, and
B K Kim, and
W Snedden, and
S Granter-Button, and
J MacDonald, and
V Gill
September 1974,
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P G Fernandez, and
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A B Galway, and
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V Gill
January 1990,
Sovetskaia meditsina,
P G Fernandez, and
J N Sharma, and
A B Galway, and
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J MacDonald, and
V Gill
August 1982,
British journal of clinical pharmacology,
P G Fernandez, and
J N Sharma, and
A B Galway, and
N Campbell, and
B K Kim, and
W Snedden, and
S Granter-Button, and
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V Gill
September 1972,
The British journal of clinical practice,
