Biomaterial Database

Pre-enucleation irradiation of uveal melanoma. 1985

D H Char, and T L Phillips

The relative efficacy of various types of treatment in preventing metastatic uveal melanoma is unclear. We have performed a phase I-II non-randomised trial to determine if patients with large (greater than 15 mm in diameter or greater than 5 mm in thickness) uveal melanomas would benefit from pre-enucleation irradiation. Twenty-eight patients were treated between 1978 and 1983 by means of 5 X 5 cm anterior wedge pair ports on a 4 me V linear accelerator. Each patient received five 4 gray (400 rad) fractions over a five-day period for a total of 20 Gy. Enucleation was performed by a single surgeon within five days after treatment. The mean follow-up of the patients was 24 months (range 7-54 months). All melanomas were histologically confirmed. Four patients (14%) have developed metastatic tumour with a mean interval between diagnosis and death of 25 months. No significant perioperative or long-term morbidity was observed.

UI	MeSH Term	Description	Entries
D008545	Melanoma	A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	Malignant Melanoma,Malignant Melanomas,Melanoma, Malignant,Melanomas,Melanomas, Malignant
D011300	Preoperative Care	Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)	Care, Preoperative,Preoperative Procedure,Preoperative Procedures,Procedure, Preoperative,Procedures, Preoperative
D002986	Clinical Trials as Topic	Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.	Clinical Trial as Topic
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013508	Ophthalmologic Surgical Procedures	Surgery performed on the eye or any of its parts.	Ophthalmologic Surgical Procedure,Ophthalmological Surgical Procedures,Procedure, Ophthalmologic Surgical,Procedures, Ophthalmologic Surgical,Surgical Procedure, Ophthalmologic,Surgical Procedures, Ophthalmologic,Ophthalmological Surgical Procedure,Procedure, Ophthalmological Surgical,Procedures, Ophthalmological Surgical,Surgical Procedure, Ophthalmological,Surgical Procedures, Ophthalmological
D014604	Uveal Neoplasms	Tumors or cancer of the UVEA.	Neoplasm, Uveal,Neoplasms, Uveal,Uveal Neoplasm