-transparent.png){kind=logo}
The minimal inhibitory concentrations (MIC) of apramycin, a unique aminocyclitol antibiotic, for 100 Escherichia coli isolates recovered from clinical cases of avian colibacillosis were determined using the agar dilution method. All isolates were inhibited at apramycin concentration of 8.0 micrograms/ml; 90 and 50% of the isolates were inhibited at 6.6 and 3.4 micrograms/ml, respectively. A commercial injectable product containing 200 mg apramycin/ml was administered intramuscularly (i.m.) to groups of 6- and 12-week-old turkeys at 10, 15 and 20 mg/kg. Apramycin was quickly absorbed from the i.m. injection site. Mean peak serum drug concentrations were reached 1 h after treatment and were 19.5, 27.5 and 36.0 micrograms/ml, respectively. The serum elimination half-life (t 1/2) of the drug ranged between 1.75 h for the 10 mg/kg dose and 2.5 h for the 20 mg/kg dose. Very low concentrations of the drug were found 24 h after treatment. Duration of serum apramycin concentrations in relation to the MIC, dose, and age of birds was determined.
P J Freidlin, and
R Bock, and
A Bernath, and
S Hoexter, and
G Ziv, and
A Fromer, and
Z Perlstein, and
S Tomer, and
Y Samberg
January 1996,
The Journal of applied bacteriology,
P J Freidlin, and
R Bock, and
A Bernath, and
S Hoexter, and
G Ziv, and
A Fromer, and
Z Perlstein, and
S Tomer, and
Y Samberg
November 1997,
Medicina clinica,
P J Freidlin, and
R Bock, and
A Bernath, and
S Hoexter, and
G Ziv, and
A Fromer, and
Z Perlstein, and
S Tomer, and
Y Samberg
October 1981,
Journal of clinical pharmacology,
P J Freidlin, and
R Bock, and
A Bernath, and
S Hoexter, and
G Ziv, and
A Fromer, and
Z Perlstein, and
S Tomer, and
Y Samberg
August 2020,
BMC veterinary research,
P J Freidlin, and
R Bock, and
A Bernath, and
S Hoexter, and
G Ziv, and
A Fromer, and
Z Perlstein, and
S Tomer, and
Y Samberg
March 1994,
Annals of clinical biochemistry,
P J Freidlin, and
R Bock, and
A Bernath, and
S Hoexter, and
G Ziv, and
A Fromer, and
Z Perlstein, and
S Tomer, and
Y Samberg
December 1988,
American journal of veterinary research,
P J Freidlin, and
R Bock, and
A Bernath, and
S Hoexter, and
G Ziv, and
A Fromer, and
Z Perlstein, and
S Tomer, and
Y Samberg
June 2018,
Avian pathology : journal of the W.V.P.A,
P J Freidlin, and
R Bock, and
A Bernath, and
S Hoexter, and
G Ziv, and
A Fromer, and
Z Perlstein, and
S Tomer, and
Y Samberg
November 1979,
Antimicrobial agents and chemotherapy,
P J Freidlin, and
R Bock, and
A Bernath, and
S Hoexter, and
G Ziv, and
A Fromer, and
Z Perlstein, and
S Tomer, and
Y Samberg
December 1975,
British journal of anaesthesia,
P J Freidlin, and
R Bock, and
A Bernath, and
S Hoexter, and
G Ziv, and
A Fromer, and
Z Perlstein, and
S Tomer, and
Y Samberg
December 1976,
Journal of the science of food and agriculture,
