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Serum and saliva levels of lincomycin were determined in 15 normal adult male volunteers after a single intramuscular injection of 600, 1000, or 1500 mg lincomycin in a three-way crossover study. The area under the serum concentration-time curve did not increase in proportion to the increase in dose. The increase in concentration of lincomycin in saliva was greater than expected for the increase in dose. There were not significant differences in elimination half-life between doses. These results suggest that the apparent clearance of lincomycin increases with increasing dose possibly because of a decrease in serum protein binding of lincomycin at high serum concentrations.
R B Smith, and
W L Lummis, and
R E Monovich, and
K A DeSante
November 1997,
Medicina clinica,
R B Smith, and
W L Lummis, and
R E Monovich, and
K A DeSante
January 1968,
The Journal of clinical pharmacology and the journal of new drugs,
R B Smith, and
W L Lummis, and
R E Monovich, and
K A DeSante
April 1989,
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie,
R B Smith, and
W L Lummis, and
R E Monovich, and
K A DeSante
July 1969,
Current therapeutic research, clinical and experimental,
R B Smith, and
W L Lummis, and
R E Monovich, and
K A DeSante
December 1975,
British journal of anaesthesia,
R B Smith, and
W L Lummis, and
R E Monovich, and
K A DeSante
December 1976,
Journal of the science of food and agriculture,
R B Smith, and
W L Lummis, and
R E Monovich, and
K A DeSante
January 1976,
Acta veterinaria Scandinavica,
R B Smith, and
W L Lummis, and
R E Monovich, and
K A DeSante
January 1983,
Medicina,
R B Smith, and
W L Lummis, and
R E Monovich, and
K A DeSante
May 1980,
Clinical pharmacology and therapeutics,
R B Smith, and
W L Lummis, and
R E Monovich, and
K A DeSante
March 1985,
Journal of veterinary pharmacology and therapeutics,
