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Using hybridization histochemistry, a technique which localizes specific mRNA populations in tissue sections with a 700 base pair recombinant DNA probe which codes for ovine renin, we have localized renin gene expression in the afferent arteriole of the juxtaglomerular apparatus (JGA) in the sheep renal cortex. Specific labelling representing renin gene expression was also found at a distance from the glomerular tuft in the walls of the afferent arteriole and also in cells in the medial layer of larger vessels of the renal cortex, specifically the interlobular arteries. These observations provide morphological evidence of renin gene expression at these sites and, combined with ultrastructural and immunocytochemical evidence suggest that renin is synthesized and stored in the afferent arteriole either within the JGA or at a distance from the glomerulus, and in the smooth muscle coat of the interlobular arteries in the sheep kidney.
I A Darby, and
P Aldred, and
R J Crawford, and
R T Fernley, and
H D Niall, and
J D Penschow, and
G B Ryan, and
J P Coghlan
March 1993,
The American journal of physiology,
I A Darby, and
P Aldred, and
R J Crawford, and
R T Fernley, and
H D Niall, and
J D Penschow, and
G B Ryan, and
J P Coghlan
July 1998,
The American journal of physiology,
I A Darby, and
P Aldred, and
R J Crawford, and
R T Fernley, and
H D Niall, and
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J P Coghlan
July 2000,
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I A Darby, and
P Aldred, and
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J D Penschow, and
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J P Coghlan
February 1992,
Journal of molecular endocrinology,
I A Darby, and
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H D Niall, and
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J P Coghlan
September 1998,
Kidney international. Supplement,
I A Darby, and
P Aldred, and
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February 2003,
Archives of physiology and biochemistry,
I A Darby, and
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August 1996,
Clinical and experimental pharmacology & physiology,
I A Darby, and
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January 1992,
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I A Darby, and
P Aldred, and
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August 1988,
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I A Darby, and
P Aldred, and
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J P Coghlan
November 2000,
Journal of cardiovascular pharmacology,
