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Pancreatic islet cell antibodies and 12 other autoantibodies were measured at the time of diabetes diagnosis in 46 Pima Indians, aged 17--47 years, and in 46 age-sex matched non-diabetic controls. Islet cell antibodies were found in only two diabetics, aged 20 and 25, compared with none of 46 controls. Neither of the subjects with islet cell antibodies had other autoantibodies. At least one type of autoantibody was found in 14 (30%) of the diabetics and in 14 controls, but none was significantly associated with diabetes. This study indicates that diabetes in the Pima Indians, even those with an onset below 25 years of age, is almost entirely of type II, in that the disease is not associated with islet cell antibodies, ketoacidosis, or insulin dependence.
W C Knowler, and
P H Bennett, and
G F Bottazzo, and
D Doniach
August 1971,
Lancet (London, England),
W C Knowler, and
P H Bennett, and
G F Bottazzo, and
D Doniach
August 1971,
Lancet (London, England),
W C Knowler, and
P H Bennett, and
G F Bottazzo, and
D Doniach
July 1971,
Lancet (London, England),
W C Knowler, and
P H Bennett, and
G F Bottazzo, and
D Doniach
May 1977,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
W C Knowler, and
P H Bennett, and
G F Bottazzo, and
D Doniach
December 1976,
Lancet (London, England),
W C Knowler, and
P H Bennett, and
G F Bottazzo, and
D Doniach
March 1991,
JPMA. The Journal of the Pakistan Medical Association,
W C Knowler, and
P H Bennett, and
G F Bottazzo, and
D Doniach
March 1980,
Medicina clinica,
W C Knowler, and
P H Bennett, and
G F Bottazzo, and
D Doniach
August 1978,
The New England journal of medicine,
W C Knowler, and
P H Bennett, and
G F Bottazzo, and
D Doniach
January 1979,
Transactions of the Association of American Physicians,
W C Knowler, and
P H Bennett, and
G F Bottazzo, and
D Doniach
February 1986,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
