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Using an indirect immunofluorescence test on suspensions of viable, insulin-producing islet cells from rats, we found that 32 per cent (28/88) of insulin-treated patients with juvenile diabetes have islet-cell-surface antibodies in their circulation. These antibodies also occurred in four of nine children with glucose intolerance, in one of 24 healthy children and in nondiabetic children with thyroid disorders. In the diabetic children, the immunofluorescent reaction was inhibited by preadsorption of serum to islet cells but was little affected by preadsorption to rat hepatocytes or erythrocytes or to acetone powders of various rat tissues, including pancreas. These results show that organ-specific, nonspecies-specific antibodies reactive with the cell surface of the islet cells can be present in serum from diabetic children, and provide an approach to investigation of immunopathological aspects of diabetes mellitus.
A Lernmark, and
Z R Freedman, and
C Hofmann, and
A H Rubenstein, and
D F Steiner, and
R L Jackson, and
R J Winter, and
H S Traisman
August 1977,
Deutsche medizinische Wochenschrift (1946),
A Lernmark, and
Z R Freedman, and
C Hofmann, and
A H Rubenstein, and
D F Steiner, and
R L Jackson, and
R J Winter, and
H S Traisman
April 1975,
Lancet (London, England),
A Lernmark, and
Z R Freedman, and
C Hofmann, and
A H Rubenstein, and
D F Steiner, and
R L Jackson, and
R J Winter, and
H S Traisman
December 1976,
Lancet (London, England),
A Lernmark, and
Z R Freedman, and
C Hofmann, and
A H Rubenstein, and
D F Steiner, and
R L Jackson, and
R J Winter, and
H S Traisman
March 1991,
JPMA. The Journal of the Pakistan Medical Association,
A Lernmark, and
Z R Freedman, and
C Hofmann, and
A H Rubenstein, and
D F Steiner, and
R L Jackson, and
R J Winter, and
H S Traisman
May 1977,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
A Lernmark, and
Z R Freedman, and
C Hofmann, and
A H Rubenstein, and
D F Steiner, and
R L Jackson, and
R J Winter, and
H S Traisman
January 1978,
Acta diabetologica latina,
A Lernmark, and
Z R Freedman, and
C Hofmann, and
A H Rubenstein, and
D F Steiner, and
R L Jackson, and
R J Winter, and
H S Traisman
March 1980,
Medicina clinica,
A Lernmark, and
Z R Freedman, and
C Hofmann, and
A H Rubenstein, and
D F Steiner, and
R L Jackson, and
R J Winter, and
H S Traisman
January 1987,
Josai Shika Daigaku kiyo. The Bulletin of the Josai Dental University,
A Lernmark, and
Z R Freedman, and
C Hofmann, and
A H Rubenstein, and
D F Steiner, and
R L Jackson, and
R J Winter, and
H S Traisman
November 1978,
The New England journal of medicine,
A Lernmark, and
Z R Freedman, and
C Hofmann, and
A H Rubenstein, and
D F Steiner, and
R L Jackson, and
R J Winter, and
H S Traisman
September 1979,
Diabetologia,
