BIOMAT Database Logo BIOMAT Database Logo

Synthesis and anthelmintic activity of 5(6)-(benzimidazol-2-ylcarbamoyl) and (4-substituted piperazin-1-yl)benzimidazoles. 1985

R Dubey, and S Abuzar, and S Sharma, and R K Chatterjee, and J C Katiyar

The synthesis of alkyl 5(6)-(benzimidazol-2-ylcarbamoyl)benzimidazole-2-carbamates (6, 7), and alkyl 5(6)-(4-substituted piperazin-1-yl)benzimidazole-2-carbamates (31-40) has been carried out. When the compounds were tested for their anthelmintic activity against Ancylostoma ceylanicum in hamsters, Hymenolepis nana in rats, Litomosoides carinii in cotton rats, and Dipetalonema viteae in Mastomys natalensis, methyl 5(6)-(4-benzoylpiperazin-1-yl)benzimidazole-2-carbamate (31), methyl 5(6)-[4-(2-furoyl)piperazin-1-yl]benzimidazole-2-carbamate and methyl 5(6)-[4-[(diethylamino)carbonyl]piperazin-1-yl]benzimidazole- -2-carbamate (36) showed 100% elimination of tapeworms H. nana at three oral doses of 100-250 mg/kg. Compounds 34 and 36 also killed the microfilariae and adult worms of L. carinii in cotton rats at an intraperitoneal dose of 30 mg/kg given for 5 days.

UI MeSH Term Description Entries
D008297 Male Males
D009115 Muridae A family of the order Rodentia containing 250 genera including the two genera Mus (MICE) and Rattus (RATS), from which the laboratory inbred strains are developed. The fifteen subfamilies are SIGMODONTINAE (New World mice and rats), CRICETINAE, Spalacinae, Myospalacinae, Lophiomyinae, ARVICOLINAE, Platacanthomyinae, Nesomyinae, Otomyinae, Rhizomyinae, GERBILLINAE, Dendromurinae, Cricetomyinae, MURINAE (Old World mice and rats), and Hydromyinae. Murids,Murid
D010879 Piperazines Compounds that are derived from PIPERAZINE.
D002219 Carbamates Derivatives of carbamic acid, H2NC( Carbamate,Aminoformic Acids,Carbamic Acids,Acids, Aminoformic,Acids, Carbamic
D002621 Chemistry A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
D003411 Arvicolinae A subfamily of MURIDAE found nearly world-wide and consisting of about 20 genera. Voles, lemmings, and muskrats are members. Clethrionomys,Cricetidae,Dicrostonyx,Lemmings,Lemmus,Mice, Red-Backed,Microtinae,Microtus,Muskrats,Ondatra,Voles,Arvicolines,Microtines,Mouse, Red-Backed,Myodes,Ondatra zibethicus,Arvicoline,Lemming,Mice, Red Backed,Microtine,Mouse, Red Backed,Muskrat,Red-Backed Mice,Red-Backed Mouse,Vole
D004154 Dipetalonema Infections Infections with nematodes of the genus DIPETALONEMA. Dipetalonemiasis,Infections, Dipetalonema,Dipetalonema Infection,Dipetalonemiases,Infection, Dipetalonema
D005260 Female Females
D006224 Cricetinae A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS. Cricetus,Hamsters,Hamster
D006373 Helminthiasis Infestation with parasitic worms of the helminth class. Nematomorpha Infections,Infections, Nematomorpha,Helminthiases,Infection, Nematomorpha,Nematomorpha Infection

Related Publications

R Dubey, and S Abuzar, and S Sharma, and R K Chatterjee, and J C Katiyar
Synthesis of 2-carbalkoxyamino-5(6)-(1-substituted piperazin-4-yl/piperazin-4-ylcarbonyl)benzimidazoles and related compounds as potential anthelmintics.
November 1984, Die Pharmazie,
R Dubey, and S Abuzar, and S Sharma, and R K Chatterjee, and J C Katiyar
Synthesis and potential anthelmintic activity of methyl-5-(4-salicyloyl-piperazin-1-yl)-benzimidazole-2-carbamates.
June 1993, Arzneimittel-Forschung,
R Dubey, and S Abuzar, and S Sharma, and R K Chatterjee, and J C Katiyar
Synthesis and antimicrobial screening of N-[2-(2/4-substituted phenyl)-1-(5/6 substituted 1H- benzimidazol-2-yl)vinyl]benzamides.
January 2012, Acta poloniae pharmaceutica,
R Dubey, and S Abuzar, and S Sharma, and R K Chatterjee, and J C Katiyar
Synthesis and antimicrobial activity of some 5-[2-(morpholin-4-yl)acetamido] and/or 5-[2-(4-substituted piperazin-1-yl)acetamido]-2-(p-substituted phenyl)benzoxazoles.
March 2005, Archiv der Pharmazie,
R Dubey, and S Abuzar, and S Sharma, and R K Chatterjee, and J C Katiyar
Synthesis and QSAR evaluation of 2-(substituted phenyl)-1H-benzimidazoles and [2-(substituted phenyl)-benzimidazol-1-yl]-pyridin-3-yl-methanones.
March 2009, European journal of medicinal chemistry,
R Dubey, and S Abuzar, and S Sharma, and R K Chatterjee, and J C Katiyar
Synthesis and potent antimicrobial activity of some novel 4-(5, 6-dichloro-1H-benzimidazol-2-yl)-N-substituted benzamides.
October 2004, Archiv der Pharmazie,
R Dubey, and S Abuzar, and S Sharma, and R K Chatterjee, and J C Katiyar
Synthesis and biological activity of some 3-(4-(substituted)-piperazin-1-yl)cinnolines.
December 2011, Molecules (Basel, Switzerland),
R Dubey, and S Abuzar, and S Sharma, and R K Chatterjee, and J C Katiyar
Design, Synthesis, and Cytotoxicity of 5-Fluoro-2-methyl-6-(4-aryl-piperazin-1-yl) Benzoxazoles.
September 2016, Molecules (Basel, Switzerland),
R Dubey, and S Abuzar, and S Sharma, and R K Chatterjee, and J C Katiyar
5-Methyl-3,3-bis-(4-methyl-piperazin-1-yl)-1-[2-(4-methyl-piperazin-1-yl)eth-yl]indolin-2-one.
June 2012, Acta crystallographica. Section E, Structure reports online,
R Dubey, and S Abuzar, and S Sharma, and R K Chatterjee, and J C Katiyar
Synthesis and antimicrobial evaluation of 2-(p-substituted phenyl)-5-[(4-substituted piperazin-l-yl)acetamido]-benzoxazoles.
January 2014, Zeitschrift fur Naturforschung. C, Journal of biosciences,
Copied contents to your clipboard!