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The degree of permeability of the alveolar-capillary barrier to low molecular weight solutes has been supposed to depend upon the radius of the epithelial pores. The bullous emphysema is a natural model in which this radius may increase because of the high tension in the bulla. Accordingly, the 99mTc-DTPA clearance may be expected to be faster than normal in lung fields including bullae. Results of the present study in which 99mTc-DTPA clearance was measured in six patients with bullous emphysema, seem to confirm this hypothesis at least to some extent. In fact, either increased or normal 99mTc-DTPA clearances were found over the lung fields including bullae communicating with the bronchial tree. Differences in both the size and the inner tension of the bullae as well as in the anatomical and functional conditions of the surrounding parenchyma are likely to account for such varying behaviour.
R Antonelli Incalzi, and
C L Maini, and
M G Bonetti, and
R Pistelli, and
G Valle
March 1997,
Clinical physiology (Oxford, England),
R Antonelli Incalzi, and
C L Maini, and
M G Bonetti, and
R Pistelli, and
G Valle
January 2009,
Hellenic journal of nuclear medicine,
R Antonelli Incalzi, and
C L Maini, and
M G Bonetti, and
R Pistelli, and
G Valle
September 1994,
Clinical physiology (Oxford, England),
R Antonelli Incalzi, and
C L Maini, and
M G Bonetti, and
R Pistelli, and
G Valle
October 1990,
Acta anaesthesiologica Scandinavica,
R Antonelli Incalzi, and
C L Maini, and
M G Bonetti, and
R Pistelli, and
G Valle
June 1988,
Respiration physiology,
R Antonelli Incalzi, and
C L Maini, and
M G Bonetti, and
R Pistelli, and
G Valle
August 1984,
Journal of applied physiology: respiratory, environmental and exercise physiology,
R Antonelli Incalzi, and
C L Maini, and
M G Bonetti, and
R Pistelli, and
G Valle
November 1990,
The American review of respiratory disease,
R Antonelli Incalzi, and
C L Maini, and
M G Bonetti, and
R Pistelli, and
G Valle
June 2002,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
R Antonelli Incalzi, and
C L Maini, and
M G Bonetti, and
R Pistelli, and
G Valle
March 1988,
Journal of applied physiology (Bethesda, Md. : 1985),
R Antonelli Incalzi, and
C L Maini, and
M G Bonetti, and
R Pistelli, and
G Valle
March 2007,
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...,
