-transparent.png){kind=logo}
Tannic acid suppressed the mutagenesis in E. coli B/r WP2 trp- induced by UV or 4-nitroquinoline 1-oxide (4NQO), but not that induced by gamma-rays or N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The depression of mutations induced by UV was most remarkable in the DNA-repair-proficient strain (WP2). Tannic acid, however, showed no bio-antimutagenic effect in the excision repair-deficient strain (WP2s uvrA- or ZA159 uvrB-) under the test conditions where no cellular toxicity was observed. The effect ceased within 30 min after UV irradiation. The inhibition of the expression of Trp+ phenotype and the delay of the first cell division after UV irradiation were not observed in the presence of tannic acid. From these results we conclude that tannic acid may enhance the excision-repair system probably by activating the repair enzymes or by interacting with DNA.
K Shimoi, and
Y Nakamura, and
I Tomita, and
T Kada
June 1997,
Mutation research,
K Shimoi, and
Y Nakamura, and
I Tomita, and
T Kada
January 1986,
Mutation research,
K Shimoi, and
Y Nakamura, and
I Tomita, and
T Kada
January 1983,
Molecular & general genetics : MGG,
K Shimoi, and
Y Nakamura, and
I Tomita, and
T Kada
February 1983,
Mutation research,
K Shimoi, and
Y Nakamura, and
I Tomita, and
T Kada
January 1992,
Bioscience, biotechnology, and biochemistry,
K Shimoi, and
Y Nakamura, and
I Tomita, and
T Kada
December 1982,
International journal of radiation biology and related studies in physics, chemistry, and medicine,
K Shimoi, and
Y Nakamura, and
I Tomita, and
T Kada
January 1982,
Folia microbiologica,
K Shimoi, and
Y Nakamura, and
I Tomita, and
T Kada
February 1998,
Mutation research,
K Shimoi, and
Y Nakamura, and
I Tomita, and
T Kada
July 1990,
Mutagenesis,
K Shimoi, and
Y Nakamura, and
I Tomita, and
T Kada
December 1989,
Mutation research,
