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TRH and its metabolite TRH-OH have been measured by specific radioimmunoassays in acid extracts of pancreas in adults and developing rats. TRH and TRH-OH immunoreactivity had the same ontogenic pattern with a maximal concentration on day 4 followed by a progressive return towards adult levels on day 20. A significant linear correlation was found between TRH levels and the TRH/TRH-OH ratio. The range of TRH/TRH-OH ratio varied from 136 +/- 1.6, at the peak of concentrations of both peptides, to 18 +/- 3.9 on day 20. Pancreatic TRH and TRH-OH had the same elution pattern as corresponding synthetic peptides both on Biogel P2 and high-pressure liquid chromatography. The origin of TRH-OH as well as its potential function need further investigations.
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January 1989,
Pharmacological research,
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April 1974,
Endocrinology,
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April 1980,
Molecular and cellular endocrinology,
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April 1994,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
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February 1974,
Nihon Naibunpi Gakkai zasshi,
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May 1984,
Acta endocrinologica,
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November 1957,
Journal of ultrastructure research,
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April 1985,
Regulatory peptides,
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January 1964,
Acta physiologica Academiae Scientiarum Hungaricae,
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January 2020,
Journal of nutritional science and vitaminology,
