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The response of growth hormone (GH) to synthetic human growth hormone releasing factor (hGRF) administered intravenously was examined in 32 neonates aged 3-28 days. GH peaked at 30 min after hGRF administration and the mean +/- SEM level of GH at maximal response was 66.4 +/- 6.2 ng/ml. In the comparison between the neonates less than 7 days old and those more than 8 days old, between the neonates less than 37 weeks and those more than 38 weeks in gestational age, between the neonates under 2,500 g and those over 2,501 g in birth body weight, and between males and females, no significant statistical differences were observed.
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