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Sixteen male Wistar strain rats were trained to have their skin conductance activity recorded through the soles of their hind limbs, and the effects of the intraventricular administration of 6-OHDA (200 micrograms) on this activity were studied. The intact rats showed skin conductance response and its habituation to repeated auditory stimuli (500 Hz, 90 dB, 1 sec). The 6-OHDA-treated rats exhibited either obliteration of the response or impairment of the habituation. The nonresponding state tended to be accompanied by a low rate of spontaneous skin conductance fluctuation, but the nonhabituating state was not accompanied by changes of the rate. The vehicle-treated rats showed no change in these activities. These electrodermal characteristics were discussed along with the CA hypothesis of schizophrenia.
K Yamamoto, and
H Kiyosumi, and
K Yamaguchi, and
T Moroji
January 1986,
Progress in neuro-psychopharmacology & biological psychiatry,
K Yamamoto, and
H Kiyosumi, and
K Yamaguchi, and
T Moroji
February 1991,
Biological psychiatry,
K Yamamoto, and
H Kiyosumi, and
K Yamaguchi, and
T Moroji
April 1984,
Experientia,
K Yamamoto, and
H Kiyosumi, and
K Yamaguchi, and
T Moroji
December 1973,
Behavioral biology,
K Yamamoto, and
H Kiyosumi, and
K Yamaguchi, and
T Moroji
September 1971,
European journal of pharmacology,
K Yamamoto, and
H Kiyosumi, and
K Yamaguchi, and
T Moroji
July 1973,
The Journal of pharmacy and pharmacology,
K Yamamoto, and
H Kiyosumi, and
K Yamaguchi, and
T Moroji
January 1984,
Endocrine research,
K Yamamoto, and
H Kiyosumi, and
K Yamaguchi, and
T Moroji
September 1972,
Science (New York, N.Y.),
K Yamamoto, and
H Kiyosumi, and
K Yamaguchi, and
T Moroji
February 1977,
Biological psychiatry,
K Yamamoto, and
H Kiyosumi, and
K Yamaguchi, and
T Moroji
February 1974,
The Journal of endocrinology,
