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Effects of intraventricular injections of 6-hydroxydopamine (6-OHDA) on adrenocortical cell proliferation in rats have been investigated by means of the colchicine metaphase-arrest technique. In the group of animals receiving 6-OHDA alone, an increase of mean mitotic activity rate (MMAR) was observed at 96 h and 144 h after injection. This rise of MMAR was completely inhibited by pretreatment of animals with desmethylimipramine (DMI) - a blocker of norepinephrine uptake. It is concluded that enhancement of ACTH secretion is responsible for the above mentioned increase of mitotic activity after 6-OHDA administration. This phenomenon is related to abolition of the inhibitory noradrenergic effect on ACTH secretion by 6-OHDA treatment. Additionally, the results suggest little or no involvement of dopaminergic neurons in early changes of ACTH secretion after intraventricular 6-OHDA.
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M K Lewińska, and
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R J Reiter
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A Lewiński, and
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Progress in neuro-psychopharmacology & biological psychiatry,
A Lewiński, and
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M Pawlikowski, and
M K Lewińska, and
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A Lewiński, and
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A Lewiński, and
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M Pawlikowski, and
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A Lewiński, and
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M K Lewińska, and
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The Journal of endocrinology,
