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The protective effect of progesterone or tamoxifen, an antiestrogenic agent, was investigated in estrogen-induced mammary carcinogenesis. Multiple mammary tumors (MT) of tubular or medullary carcinoma type developed at a high rate following prolonged treatment of ovariectomized W/Fu rats with diethylstilbestrol or 17 beta-estradiol. All MTs were located adjacent to the nipple and were slow-growing. The induction rate, multiplicity and size of estrogen-induced MTs were reduced by the simultaneous administration of either progesterone or tamoxifen. The estrogen-induced pituitary tumorigenesis was effectively inhibited by tamoxifen treatment, but it was not affected by progesterone. The results indicated that the inhibitory effect of progesterone or tamoxifen in estrogen-induced carcinogenesis is attributable to interference with the binding of estrogen to the estrogen receptors on the target cells.
A Inoh, and
K Kamiya, and
Y Fujii, and
K Yokoro
March 2008,
Proceedings of the National Academy of Sciences of the United States of America,
A Inoh, and
K Kamiya, and
Y Fujii, and
K Yokoro
January 2011,
PloS one,
A Inoh, and
K Kamiya, and
Y Fujii, and
K Yokoro
September 1991,
Bone and mineral,
A Inoh, and
K Kamiya, and
Y Fujii, and
K Yokoro
May 2007,
Oncogene,
A Inoh, and
K Kamiya, and
Y Fujii, and
K Yokoro
May 1978,
Pharmacology, biochemistry, and behavior,
A Inoh, and
K Kamiya, and
Y Fujii, and
K Yokoro
February 1975,
Steroids,
A Inoh, and
K Kamiya, and
Y Fujii, and
K Yokoro
October 1977,
Endocrinology,
A Inoh, and
K Kamiya, and
Y Fujii, and
K Yokoro
April 2016,
Neuroscience letters,
A Inoh, and
K Kamiya, and
Y Fujii, and
K Yokoro
July 1993,
Cancer letters,
A Inoh, and
K Kamiya, and
Y Fujii, and
K Yokoro
September 1975,
Hormones and behavior,
