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An experimental study was conducted in rats to evaluate the sensitivity of the liver to infrared hyperthermia. A 15-min hyperthermia session treating only the liver was done in rats with a normal hepatic parenchyma and in rats with hepatocarcinoma induced by chronic 3'-diethylaminoazobenzene intoxication, at various ranges of intrahepatic temperature. In normal rats, 40-42 degrees C hyperthermia was well tolerated, but the mortality rate increased when the intrahepatic temperature exceeded 42 degrees C. In rats with tumors, a 40-42 degrees C hyperthermia session was well tolerated in case of small tumors, but resulted in a high mortality rate in case of large tumors. In all cases, death occurred as a consequence of liver injury. This study using a simple method of hyperthermia defines the thermosensitivity of the neoplastic or normal rat liver and provides a basis for further investigations on the effect of hyperthermia on experimental liver tumors.
R Adam, and
L Poggi, and
D Houssin, and
M Capron, and
J Morin, and
M Gigou, and
J L Miramand, and
A M Szekely, and
H Bismuth
August 1957,
Zeitschrift fur arztliche Fortbildung,
R Adam, and
L Poggi, and
D Houssin, and
M Capron, and
J Morin, and
M Gigou, and
J L Miramand, and
A M Szekely, and
H Bismuth
January 2009,
Journal of environmental sciences (China),
R Adam, and
L Poggi, and
D Houssin, and
M Capron, and
J Morin, and
M Gigou, and
J L Miramand, and
A M Szekely, and
H Bismuth
January 2000,
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group,
R Adam, and
L Poggi, and
D Houssin, and
M Capron, and
J Morin, and
M Gigou, and
J L Miramand, and
A M Szekely, and
H Bismuth
May 1970,
Cancer research,
R Adam, and
L Poggi, and
D Houssin, and
M Capron, and
J Morin, and
M Gigou, and
J L Miramand, and
A M Szekely, and
H Bismuth
May 1959,
Bollettino della Societa italiana di biologia sperimentale,
R Adam, and
L Poggi, and
D Houssin, and
M Capron, and
J Morin, and
M Gigou, and
J L Miramand, and
A M Szekely, and
H Bismuth
January 1980,
Annals of the New York Academy of Sciences,
R Adam, and
L Poggi, and
D Houssin, and
M Capron, and
J Morin, and
M Gigou, and
J L Miramand, and
A M Szekely, and
H Bismuth
March 1988,
International journal of radiation oncology, biology, physics,
R Adam, and
L Poggi, and
D Houssin, and
M Capron, and
J Morin, and
M Gigou, and
J L Miramand, and
A M Szekely, and
H Bismuth
January 1964,
Oncologia,
R Adam, and
L Poggi, and
D Houssin, and
M Capron, and
J Morin, and
M Gigou, and
J L Miramand, and
A M Szekely, and
H Bismuth
September 1985,
Cancer,
R Adam, and
L Poggi, and
D Houssin, and
M Capron, and
J Morin, and
M Gigou, and
J L Miramand, and
A M Szekely, and
H Bismuth
October 1971,
The Biochemical journal,
