Biomaterial Database

Antibody-mediated protection of guinea-pigs against infection with Treponema pallidum. 1985

C S Pavia, and C J Niederbuhl, and J Saunders

The results of this study demonstrate that passive transfer of immune serum containing high titres of treponemal antibody into normal guinea-pigs significantly lowered the percentage of animals developing chancre-like lesions, but did not prevent the dissemination of organisms into the draining lymph nodes after these recipients were challenged with virulent treponemes. Similar levels of partial protection against cutaneous syphilitic infection occurred in guinea-pigs receiving partially purified anti-treponemal immunoglobulins, while immune serum depleted of IgG by treatment with Protein A was totally unprotective. Western blotting analysis revealed the presence of several Treponema pallidum polypeptides detectable by immune guinea-pig IgG. These findings provide direct evidence to suggest that syphilitic infection induces the formation of serum factors, residing primarily in the IgG fraction of immune serum, that are capable of providing a limited form of resistance to symptomatic disease.

UI	MeSH Term	Description	Entries
D007074	Immunoglobulin G	The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.	Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007116	Immunization, Passive	Transfer of immunity from immunized to non-immune host by administration of serum antibodies, or transplantation of lymphocytes (ADOPTIVE TRANSFER).	Convalescent Plasma Therapy,Immunoglobulin Therapy,Immunotherapy, Passive,Normal Serum Globulin Therapy,Passive Antibody Transfer,Passive Transfer of Immunity,Serotherapy,Passive Immunotherapy,Therapy, Immunoglobulin,Antibody Transfer, Passive,Passive Immunization,Therapy, Convalescent Plasma,Transfer, Passive Antibody
D008198	Lymph Nodes	They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.	Lymph Node,Node, Lymph,Nodes, Lymph
D005779	Immunodiffusion	Technique involving the diffusion of antigen or antibody through a semisolid medium, usually agar or agarose gel, with the result being a precipitin reaction.	Gel Diffusion Tests,Diffusion Test, Gel,Diffusion Tests, Gel,Gel Diffusion Test,Immunodiffusions,Test, Gel Diffusion,Tests, Gel Diffusion
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000907	Antibodies, Bacterial	Immunoglobulins produced in a response to BACTERIAL ANTIGENS.	Bacterial Antibodies
D013587	Syphilis	A contagious venereal disease caused by the spirochete TREPONEMA PALLIDUM.	Great Pox
D014210	Treponema pallidum	The causative agent of venereal and non-venereal syphilis as well as yaws.