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Seven children with central precocious puberty and either neurofibromatosis and/or optic gliomas were referred to the National Institutes of Health, Bethesda, Md, for evaluation and treatment with the long-acting luteinizing hormone releasing hormone analogue (LHRHa) D-Trp6-Pro9-NEt-LHRH. Only six of the seven children chose to receive treatment. Four children presented with neurofibromatosis, three of whom also had optic gliomas; the remaining three children had isolated optic gliomas, without other neurocutaneous stigmas. All had central precocious puberty mediated by activation of the hypothalamic-pituitary-gonadal axis. Six months of LHRHa therapy caused suppression of gonadotropin and sex steroid levels, stabilization or regression of secondary sexual characteristics, and decreases in growth velocity and the rate of bone age maturation. We conclude that LHRHa therapy is effective in the treatment of central precocious puberty secondary to neurofibromatosis and/or optic gliomas.
L Laue, and
F Comite, and
K Hench, and
D L Loriaux, and
G B Cutler, and
O H Pescovitz
October 1989,
Australian paediatric journal,
L Laue, and
F Comite, and
K Hench, and
D L Loriaux, and
G B Cutler, and
O H Pescovitz
February 1990,
Journal of paediatrics and child health,
L Laue, and
F Comite, and
K Hench, and
D L Loriaux, and
G B Cutler, and
O H Pescovitz
January 1990,
Acta paediatrica Scandinavica,
L Laue, and
F Comite, and
K Hench, and
D L Loriaux, and
G B Cutler, and
O H Pescovitz
December 1981,
The New England journal of medicine,
L Laue, and
F Comite, and
K Hench, and
D L Loriaux, and
G B Cutler, and
O H Pescovitz
November 1984,
The Journal of clinical endocrinology and metabolism,
L Laue, and
F Comite, and
K Hench, and
D L Loriaux, and
G B Cutler, and
O H Pescovitz
August 1988,
The Journal of clinical endocrinology and metabolism,
L Laue, and
F Comite, and
K Hench, and
D L Loriaux, and
G B Cutler, and
O H Pescovitz
January 1986,
The Journal of pediatrics,
L Laue, and
F Comite, and
K Hench, and
D L Loriaux, and
G B Cutler, and
O H Pescovitz
May 1984,
The Journal of clinical endocrinology and metabolism,
L Laue, and
F Comite, and
K Hench, and
D L Loriaux, and
G B Cutler, and
O H Pescovitz
March 1993,
Acta paediatrica (Oslo, Norway : 1992). Supplement,
L Laue, and
F Comite, and
K Hench, and
D L Loriaux, and
G B Cutler, and
O H Pescovitz
January 2005,
Endocrine development,
