-transparent.png){kind=logo}
Twenty-nine patients with advanced malignant melanoma were randomized to receive DTIC at a dose of 200 mg/m2 iv on Days 1-5 and cis-dichlorodiammine-platinum(II) at a dose of 40 mg/m2 iv on Days 1 and 4, repeated every 4 weeks (group A), or the same drugs plus procarbazine at a dose of 75 mg/m2 orally daily on Days 1-8 and vincristine at a dose of 1.4 mg/m2 iv on Day 1 (group B). These drugs were generally well-tolerated, but five of 16 patients in group A and six of 13 patients in group B required dose modification for either hematologic or renal toxicity. There were six objective responses among 16 patients in group A including one complete regression, while there were two objective responses among 13 patients in group B.
C P Karakousis, and
E P Getaz, and
S Bjornsson, and
E S Henderson, and
M Irequi, and
L Martinez, and
J Ospina, and
J Cavins, and
H Preisler, and
E Holyoke, and
O Holtermann
January 1979,
Cancer treatment reports,
C P Karakousis, and
E P Getaz, and
S Bjornsson, and
E S Henderson, and
M Irequi, and
L Martinez, and
J Ospina, and
J Cavins, and
H Preisler, and
E Holyoke, and
O Holtermann
January 1978,
Cancer treatment reports,
C P Karakousis, and
E P Getaz, and
S Bjornsson, and
E S Henderson, and
M Irequi, and
L Martinez, and
J Ospina, and
J Cavins, and
H Preisler, and
E Holyoke, and
O Holtermann
January 1980,
Journal of cancer research and clinical oncology,
C P Karakousis, and
E P Getaz, and
S Bjornsson, and
E S Henderson, and
M Irequi, and
L Martinez, and
J Ospina, and
J Cavins, and
H Preisler, and
E Holyoke, and
O Holtermann
March 1979,
Cancer treatment reports,
C P Karakousis, and
E P Getaz, and
S Bjornsson, and
E S Henderson, and
M Irequi, and
L Martinez, and
J Ospina, and
J Cavins, and
H Preisler, and
E Holyoke, and
O Holtermann
May 1986,
Gan to kagaku ryoho. Cancer & chemotherapy,
C P Karakousis, and
E P Getaz, and
S Bjornsson, and
E S Henderson, and
M Irequi, and
L Martinez, and
J Ospina, and
J Cavins, and
H Preisler, and
E Holyoke, and
O Holtermann
May 1976,
Drug and therapeutics bulletin,
C P Karakousis, and
E P Getaz, and
S Bjornsson, and
E S Henderson, and
M Irequi, and
L Martinez, and
J Ospina, and
J Cavins, and
H Preisler, and
E Holyoke, and
O Holtermann
April 1979,
Cancer treatment reports,
C P Karakousis, and
E P Getaz, and
S Bjornsson, and
E S Henderson, and
M Irequi, and
L Martinez, and
J Ospina, and
J Cavins, and
H Preisler, and
E Holyoke, and
O Holtermann
January 1979,
Cancer treatment reports,
C P Karakousis, and
E P Getaz, and
S Bjornsson, and
E S Henderson, and
M Irequi, and
L Martinez, and
J Ospina, and
J Cavins, and
H Preisler, and
E Holyoke, and
O Holtermann
April 1982,
Gan to kagaku ryoho. Cancer & chemotherapy,
C P Karakousis, and
E P Getaz, and
S Bjornsson, and
E S Henderson, and
M Irequi, and
L Martinez, and
J Ospina, and
J Cavins, and
H Preisler, and
E Holyoke, and
O Holtermann
January 1979,
Cancer treatment reports,
