Biomaterial Database

Mass spectrometer monitoring of expired carbon dioxide in critically ill neonates. 1985

R G Meny, and A M Bhat, and E Aranas

Seventy-five paired comparisons of expired carbon dioxide tension (PECO2) and PaCO2 were obtained to evaluate the clinical usefulness of a mass spectrometer for monitoring PECO2 in critically ill neonates and to explore the factors that influence the PaCO2-PECO2 gradient. Nine neonates with a mean birth weight of 2.18 kg and a mean gestational age of 34 wk were studied during continuous positive-pressure ventilation. When PaCO2 was between 26 and 50 torr, this variable was linearly related to PECO2 by the equation: PaCO2 = 23.42 + .50 PECO2, r = +0.69 (p less than .001). Mean daily gradients for severe pulmonary disease (n = 9; mean 10.5 +/- 4.4 [SD] torr) were significantly (p less than .01) higher than those for moderate disease (n = 10; mean 3.9 +/- 3.1 torr); however, 61.3% of the gradients were no greater than 10 torr. Expiratory times no greater than 1.0 sec were associated with significantly (p less than .001) higher gradients (n = 33; mean 12.2 +/- 3.8 torr) than those over 1.0 sec (n = 42; mean 5.4 +/- 4.9 torr). This was, in part, due to the response time of the mass spectrometer system (0.68 sec to 63% of a step change in CO2). The continuous monitoring of PECO2 was especially helpful in the care of two neonates. We hypothesize that a decrease in the response time would improve the correlation between PaCO2 and PECO2 and thereby enhance the usefulness of this device as a trend monitor.

UI	MeSH Term	Description	Entries
D007231	Infant, Newborn	An infant during the first 28 days after birth.	Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D008991	Monitoring, Physiologic	The continuous measurement of physiological processes, blood pressure, heart rate, renal output, reflexes, respiration, etc., in a patient or experimental animal; includes pharmacologic monitoring, the measurement of administered drugs or their metabolites in the blood, tissues, or urine.	Patient Monitoring,Monitoring, Physiological,Physiologic Monitoring,Monitoring, Patient,Physiological Monitoring
D010100	Oxygen	An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.	Dioxygen,Oxygen-16,Oxygen 16
D011175	Positive-Pressure Respiration	A method of mechanical ventilation in which pressure is maintained to increase the volume of gas remaining in the lungs at the end of expiration, thus reducing the shunting of blood through the lungs and improving gas exchange.	Positive End-Expiratory Pressure,Positive-Pressure Ventilation,End-Expiratory Pressure, Positive,End-Expiratory Pressures, Positive,Positive End Expiratory Pressure,Positive End-Expiratory Pressures,Positive Pressure Respiration,Positive Pressure Ventilation,Positive-Pressure Respirations,Positive-Pressure Ventilations,Pressure, Positive End-Expiratory,Pressures, Positive End-Expiratory,Respiration, Positive-Pressure,Respirations, Positive-Pressure,Ventilation, Positive-Pressure,Ventilations, Positive-Pressure
D012119	Respiration	The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (	Breathing
D012127	Respiratory Distress Syndrome, Newborn	A condition of the newborn marked by DYSPNEA with CYANOSIS, heralded by such prodromal signs as dilatation of the alae nasi, expiratory grunt, and retraction of the suprasternal notch or costal margins, mostly frequently occurring in premature infants, children of diabetic mothers, and infants delivered by cesarean section, and sometimes with no apparent predisposing cause.	Infantile Respiratory Distress Syndrome,Neonatal Respiratory Distress Syndrome,Respiratory Distress Syndrome, Infant
D002245	Carbon Dioxide	A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.	Carbonic Anhydride,Anhydride, Carbonic,Dioxide, Carbon
D003422	Critical Care	Health care provided to a critically ill patient during a medical emergency or crisis.	Intensive Care,Intensive Care, Surgical,Surgical Intensive Care,Care, Critical,Care, Intensive,Care, Surgical Intensive
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013058	Mass Spectrometry	An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.	Mass Spectroscopy,Spectrometry, Mass,Spectroscopy, Mass,Spectrum Analysis, Mass,Analysis, Mass Spectrum,Mass Spectrum Analysis,Analyses, Mass Spectrum,Mass Spectrum Analyses,Spectrum Analyses, Mass