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Automated digoxin immunoassays with the Abbott TDx, Dade Stratus, and Du Pont aca were evaluated against an RIA similar to the Centers for Disease Control Candidate Reference Method. All three automated methods correlated poorly with the reference method. Particularly disconcerting were the falsely increased values (up to 0.6 micrograms/L) obtained by the Stratus for blank specimens. We discuss the inaccuracies of the results in terms of sample matrix effects, calibrator problems, lot-to-lot reagent variation, and our laboratory requirements. We strongly support the acceptance of the CDC Candidate Reference Method for digoxin and the establishment of a standardized protocol for determining the accuracy of digoxin measurements.
D R Clark, and
R L Inloes, and
S M Kalman, and
H H Sussman
January 1986,
Clinical chemistry,
D R Clark, and
R L Inloes, and
S M Kalman, and
H H Sussman
March 1987,
Clinical chemistry,
D R Clark, and
R L Inloes, and
S M Kalman, and
H H Sussman
July 1987,
Clinical chemistry,
D R Clark, and
R L Inloes, and
S M Kalman, and
H H Sussman
November 1984,
Clinical chemistry,
D R Clark, and
R L Inloes, and
S M Kalman, and
H H Sussman
January 1979,
Clinical chemistry,
D R Clark, and
R L Inloes, and
S M Kalman, and
H H Sussman
March 1984,
Clinical chemistry,
D R Clark, and
R L Inloes, and
S M Kalman, and
H H Sussman
September 1982,
Clinical chemistry,
D R Clark, and
R L Inloes, and
S M Kalman, and
H H Sussman
September 1978,
Clinical chemistry,
D R Clark, and
R L Inloes, and
S M Kalman, and
H H Sussman
November 1984,
Clinical chemistry,
D R Clark, and
R L Inloes, and
S M Kalman, and
H H Sussman
May 1983,
Clinical chemistry,
