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Rat thyroid follicles in both the normal and the inverted configuration have been cultured in suspension. It has been found that normal follicles (i.e., those having a structural organization similar to the follicles in vivo) express most functional properties of the thyroid gland. They trap iodide, synthesize, secrete, and iodinate thyroglobulin, and secrete thyroid hormone into the culture medium. On the contrary, in inverted follicles (i.e., those having a cell polarity reversed with respect to normal) we were unable to detect expression of some of these functions. We conclude that both the follicular organization and the proper cell polarity are needed for the full expression of thyroid functional properties.
C Tacchetti, and
C Zurzolo, and
A Monticelli, and
L Nitsch
April 1982,
Experimental cell research,
C Tacchetti, and
C Zurzolo, and
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L Nitsch
September 1982,
Molecular and cellular endocrinology,
C Tacchetti, and
C Zurzolo, and
A Monticelli, and
L Nitsch
June 1990,
Molecular and cellular endocrinology,
C Tacchetti, and
C Zurzolo, and
A Monticelli, and
L Nitsch
January 1980,
Proceedings of the National Academy of Sciences of the United States of America,
C Tacchetti, and
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L Nitsch
April 1990,
Acta endocrinologica,
C Tacchetti, and
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A Monticelli, and
L Nitsch
August 1982,
The Journal of cell biology,
C Tacchetti, and
C Zurzolo, and
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L Nitsch
May 1980,
Proceedings of the National Academy of Sciences of the United States of America,
C Tacchetti, and
C Zurzolo, and
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September 1987,
Scanning microscopy,
C Tacchetti, and
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May 2021,
Endocrine connections,
C Tacchetti, and
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L Nitsch
September 1980,
The Journal of cell biology,
