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Peripheral vascular resistance (PVR) and thromboxane A2(TxA2) synthesis after the cold pressor test were investigated in different subsets of patients with angina (10 with stable effort angina, 36 with resting angina [24 in an active phase and 12 in an inactive phase], and five with Prinzmetal's variant angina) and in 41 control subjects of equivalent age and risk factors. Left ventricular end-diastolic pressure, ejection fraction, extent of coronary angiographic lesions, and baseline PVR were not significantly different among the various patient groups. In all patient groups, except those with variant angina, the cold pressor test resulted in a higher increase in PVR than in the control subjects (p less than .001 for all groups). In patients with variant angina the vasoconstrictor response was increased only in proximity (about 1 hr) to ischemic attacks. In patients with active resting angina the vasoconstrictor response was on the average four times longer than that in patients with effort angina and with inactive resting angina (p less than .001). This exaggerated vasoconstrictor response was associated with elevated TxA2 resting levels in plasma and with increased TxA2 synthesis after the cold pressor test. A linear relationship was found between the area of the vascular response and the area of TxA2 production after the cold pressor test in patients with active resting angina (r = .87, p less than .001). The increased TxA2 synthesis and the inappropriate increase of peripheral vascular response to sympathetic stimulation revert back to normal in the inactive phase.(ABSTRACT TRUNCATED AT 250 WORDS)
G G Neri Serneri, and
G F Gensini, and
G Masotti, and
R Abbate, and
L Poggesi, and
R Laureano, and
D Prisco, and
P G Rogasi, and
S Castellani
September 1987,
American heart journal,
G G Neri Serneri, and
G F Gensini, and
G Masotti, and
R Abbate, and
L Poggesi, and
R Laureano, and
D Prisco, and
P G Rogasi, and
S Castellani
June 1991,
Journal of cardiovascular pharmacology,
G G Neri Serneri, and
G F Gensini, and
G Masotti, and
R Abbate, and
L Poggesi, and
R Laureano, and
D Prisco, and
P G Rogasi, and
S Castellani
June 1984,
The American journal of cardiology,
G G Neri Serneri, and
G F Gensini, and
G Masotti, and
R Abbate, and
L Poggesi, and
R Laureano, and
D Prisco, and
P G Rogasi, and
S Castellani
July 1983,
Angiology,
G G Neri Serneri, and
G F Gensini, and
G Masotti, and
R Abbate, and
L Poggesi, and
R Laureano, and
D Prisco, and
P G Rogasi, and
S Castellani
December 1984,
Clinical science (London, England : 1979),
G G Neri Serneri, and
G F Gensini, and
G Masotti, and
R Abbate, and
L Poggesi, and
R Laureano, and
D Prisco, and
P G Rogasi, and
S Castellani
January 1997,
Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology,
G G Neri Serneri, and
G F Gensini, and
G Masotti, and
R Abbate, and
L Poggesi, and
R Laureano, and
D Prisco, and
P G Rogasi, and
S Castellani
April 2024,
Hypertension (Dallas, Tex. : 1979),
G G Neri Serneri, and
G F Gensini, and
G Masotti, and
R Abbate, and
L Poggesi, and
R Laureano, and
D Prisco, and
P G Rogasi, and
S Castellani
September 1990,
Cardiovascular research,
G G Neri Serneri, and
G F Gensini, and
G Masotti, and
R Abbate, and
L Poggesi, and
R Laureano, and
D Prisco, and
P G Rogasi, and
S Castellani
January 1985,
The Journal of cardiovascular surgery,
G G Neri Serneri, and
G F Gensini, and
G Masotti, and
R Abbate, and
L Poggesi, and
R Laureano, and
D Prisco, and
P G Rogasi, and
S Castellani
April 1989,
International journal of microcirculation, clinical and experimental,
