Biomaterial Database

A servo-system for constant pressure perfusion of the isolated rat kidney. 1986

R C Scaduto, and A C Schoolwerth

A technical difficulty in perfusion of the isolated rat kidney has been the regulation of perfusion pressure. Since perfusion pressure is an important determinant of renal function, this parameter should be well regulated for experimental consistency. A servo-system is described that uses analog circuitry to calculate and maintain the cannula tip pressure for perfusion of the isolated kidney. The system is sufficiently responsive to maintain a constant perfusion pressure during the rapid changes in renal resistance caused by addition of angiotensin II or epinephrine to the perfusate. Analog outputs are provided for the recording of perfusion flow rate, perfusion pressure, and renal resistance.

UI	MeSH Term	Description	Entries
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D010477	Perfusion	Treatment process involving the injection of fluid into an organ or tissue.	Perfusions
D005246	Feedback	A mechanism of communication within a system in that the input signal generates an output response which returns to influence the continued activity or productivity of that system.	Feedbacks
D006874	Hydrostatic Pressure	The pressure due to the weight of fluid.	Hydrostatic Pressures,Pressure, Hydrostatic,Pressures, Hydrostatic
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014655	Vascular Resistance	The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.	Peripheral Resistance,Total Peripheral Resistance,Pulmonary Vascular Resistance,Systemic Vascular Resistance,Peripheral Resistance, Total,Resistance, Peripheral,Resistance, Pulmonary Vascular,Resistance, Systemic Vascular,Resistance, Total Peripheral,Resistance, Vascular,Vascular Resistance, Pulmonary,Vascular Resistance, Systemic