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To determine the effect of vasodilator-induced hypotension on the relationship between transcutaneous PO2 (PtcO2) and PaO2, six mongrel dogs and 20 patients were monitored before and during infusion of sodium nitroprusside (SNP), with PtcO2 sensors heated to 45 degrees C. First, SNP infusion was used to lower the mean arterial pressure (MAP) of anesthetized dogs, in steps of approximately 25%, to 49 +/- 3 (SD) mm Hg. There were no significant changes in cardiac output, oxygen consumption, PtcO2, PaO2, or PtcO2 index (PtcO2/PaO2). Twenty patients were monitored during general anesthesia. Fifteen patients were being treated for acute hypertension with SNP, and in five patients hypotension was induced with SNP to minimize blood loss. There was a significant decrease in MAP, PaO2, and PtcO2, and a significant increase in alveolar-arterial PO2 difference during SNP infusion. PtcO2 index did not change significantly from its preinfusion value in either group.
K K Tremper, and
K S Waxman, and
R A Applebaum, and
H N Konchigeri, and
J Zaccari, and
S M Hufstedler, and
M Farnum
October 1981,
Critical care medicine,
K K Tremper, and
K S Waxman, and
R A Applebaum, and
H N Konchigeri, and
J Zaccari, and
S M Hufstedler, and
M Farnum
December 1979,
Critical care medicine,
K K Tremper, and
K S Waxman, and
R A Applebaum, and
H N Konchigeri, and
J Zaccari, and
S M Hufstedler, and
M Farnum
January 1985,
International journal of clinical monitoring and computing,
K K Tremper, and
K S Waxman, and
R A Applebaum, and
H N Konchigeri, and
J Zaccari, and
S M Hufstedler, and
M Farnum
June 1991,
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae,
K K Tremper, and
K S Waxman, and
R A Applebaum, and
H N Konchigeri, and
J Zaccari, and
S M Hufstedler, and
M Farnum
October 1991,
Pediatric cardiology,
K K Tremper, and
K S Waxman, and
R A Applebaum, and
H N Konchigeri, and
J Zaccari, and
S M Hufstedler, and
M Farnum
February 1980,
Pediatrics,
K K Tremper, and
K S Waxman, and
R A Applebaum, and
H N Konchigeri, and
J Zaccari, and
S M Hufstedler, and
M Farnum
January 1976,
European journal of intensive care medicine,
K K Tremper, and
K S Waxman, and
R A Applebaum, and
H N Konchigeri, and
J Zaccari, and
S M Hufstedler, and
M Farnum
June 1976,
Hospital practice,
K K Tremper, and
K S Waxman, and
R A Applebaum, and
H N Konchigeri, and
J Zaccari, and
S M Hufstedler, and
M Farnum
January 1986,
Panminerva medica,
K K Tremper, and
K S Waxman, and
R A Applebaum, and
H N Konchigeri, and
J Zaccari, and
S M Hufstedler, and
M Farnum
May 1980,
Intensive care medicine,
