Biomaterial Database

[Sudden deafness--on the age dependence of therapy results with reference to naftidrofuryl (Dusodril)]. 1985

W Koehn, and H J Nickol

The results of treatment of 100 patients with sudden sensorineural hearing loss were analysed in three age groups (under 30, 30-60, over 60 years). The basic therapy consisted of Dextran, Diazepam and Vitamins. One half of the patients in each age group was treated with Naftidrofuryl (Dusodril) too. Sudden hearing loss was more profound in the elderly patients than in the younger ones, and the hearing gain (%) decreased with increasing age. The absolute (dB) hearing gain was more or less independent of age and Dusodril, and for all patients averaged 21 dB. Only the hearing gain (%) of the 30-60 year old patients treated with Dusodril was significantly greater than that of the control group treated without Dusodril.

UI	MeSH Term	Description	Entries
D008144	Loudness Perception	The perceived attribute of a sound which corresponds to the physical attribute of intensity.	Loudness Perceptions,Perception, Loudness,Perceptions, Loudness
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009257	Nafronyl	A drug used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be a spasmolytic. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1310) It may also be an antagonist at 5HT-2 serotonin receptors.	Nafronyloxalate,Naftidrofuryl,Artocoron,Azunaftil,Di-Actane,Dusodril,Gévatran,LS-121,Nafronyl Oxalate,Nafti Von Ct,Nafti-Puren,Nafti-Ratiopharm,Naftifurin Oxalate,Naftilong,Naftilux,Praxilene,Praxilène,Di Actane,LS 121,LS121,Nafti Puren,Nafti Ratiopharm,NaftiRatiopharm,Oxalate, Nafronyl,Oxalate, Naftifurin
D010898	Pitch Perception	A dimension of auditory sensation varying with cycles per second of the sound stimulus.	Perception, Pitch,Perceptions, Pitch,Pitch Perceptions
D003639	Hearing Loss, Sudden	Sensorineural hearing loss which develops suddenly over a period of hours or a few days. It varies in severity from mild to total deafness. Sudden deafness can be due to head trauma, vascular diseases, infections, or can appear without obvious cause or warning.	Deafness, Sudden,Sudden Deafness,Sudden Hearing Loss
D004334	Drug Administration Schedule	Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.	Administration Schedule, Drug,Administration Schedules, Drug,Drug Administration Schedules,Schedule, Drug Administration,Schedules, Drug Administration
D004359	Drug Therapy, Combination	Therapy with two or more separate preparations given for a combined effect.	Combination Chemotherapy,Polychemotherapy,Chemotherapy, Combination,Combination Drug Therapy,Drug Polytherapy,Therapy, Combination Drug,Chemotherapies, Combination,Combination Chemotherapies,Combination Drug Therapies,Drug Polytherapies,Drug Therapies, Combination,Polychemotherapies,Polytherapies, Drug,Polytherapy, Drug,Therapies, Combination Drug
D005260	Female		Females
D005663	Furans	Compounds with a 5-membered ring of four carbons and an oxygen. They are aromatic heterocycles. The reduced form is tetrahydrofuran.	Tetrahydrofurans