-transparent.png){kind=logo}
A morphine infusion paradigm was used to investigate opioid mechanisms in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis in depression. The subjects were unmedicated psychiatric inpatients and healthy volunteers. Morphine suppressed cortisol secretion. Early resumption of cortisol secretion was associated with a diagnosis of major depression and abnormal dexamethasone suppression test results. Our data suggest that the hyperactivity of the HPA axis observed in depression is abnormally resistant to opioid inhibition as well as glucocorticoid feedback.
Related Publications
A P Zis, and
R F Haskett, and
A A Albala, and
B J Carroll, and
N E Lohr
June 2015,
Neuroscience bulletin,
A P Zis, and
R F Haskett, and
A A Albala, and
B J Carroll, and
N E Lohr
October 1985,
The British journal of psychiatry : the journal of mental science,
A P Zis, and
R F Haskett, and
A A Albala, and
B J Carroll, and
N E Lohr
April 2002,
Archives of physiology and biochemistry,
A P Zis, and
R F Haskett, and
A A Albala, and
B J Carroll, and
N E Lohr
August 2002,
Psychological medicine,
A P Zis, and
R F Haskett, and
A A Albala, and
B J Carroll, and
N E Lohr
November 1992,
Biological psychiatry,
A P Zis, and
R F Haskett, and
A A Albala, and
B J Carroll, and
N E Lohr
December 1988,
The Journal of endocrinology,
A P Zis, and
R F Haskett, and
A A Albala, and
B J Carroll, and
N E Lohr
January 1996,
Life sciences,
A P Zis, and
R F Haskett, and
A A Albala, and
B J Carroll, and
N E Lohr
January 1987,
Advances in biochemical psychopharmacology,
A P Zis, and
R F Haskett, and
A A Albala, and
B J Carroll, and
N E Lohr
January 1998,
Life sciences,
A P Zis, and
R F Haskett, and
A A Albala, and
B J Carroll, and
N E Lohr
June 1998,
The Psychiatric clinics of North America,
