-transparent.png){kind=logo}
To elucidate the effects of PSK, a protein-bound polysaccharide from Coriolus versicolor, on gene expression in tumor cells, we prepared cDNA clone libraries from PSK-treated and untreated cells of a rat ascites hepatoma line, AH66, which was previously shown to be susceptible to the antitumor action of this compound. Two PSK-induced and one suppressed cDNA clones were selected from these libraries by using a differential colony hybridization and RNA blot hybridization. PSK was thus shown to have a direct effect on the transcription and consequently on the translation of tumor cells.
Related Publications
K Hirose, and
M Hakozaki, and
K Matsunaga, and
C Yoshikumi, and
T Hotta, and
M Yanagisawa, and
M Yamamoto, and
H Endo
January 1988,
International journal of immunopharmacology,
K Hirose, and
M Hakozaki, and
K Matsunaga, and
C Yoshikumi, and
T Hotta, and
M Yanagisawa, and
M Yamamoto, and
H Endo
January 1994,
In vivo (Athens, Greece),
K Hirose, and
M Hakozaki, and
K Matsunaga, and
C Yoshikumi, and
T Hotta, and
M Yanagisawa, and
M Yamamoto, and
H Endo
January 1988,
International journal of immunopharmacology,
K Hirose, and
M Hakozaki, and
K Matsunaga, and
C Yoshikumi, and
T Hotta, and
M Yanagisawa, and
M Yamamoto, and
H Endo
January 1991,
Anticancer research,
K Hirose, and
M Hakozaki, and
K Matsunaga, and
C Yoshikumi, and
T Hotta, and
M Yanagisawa, and
M Yamamoto, and
H Endo
September 1984,
Journal of pharmacobio-dynamics,
K Hirose, and
M Hakozaki, and
K Matsunaga, and
C Yoshikumi, and
T Hotta, and
M Yanagisawa, and
M Yamamoto, and
H Endo
January 1992,
Biotherapy (Dordrecht, Netherlands),
K Hirose, and
M Hakozaki, and
K Matsunaga, and
C Yoshikumi, and
T Hotta, and
M Yanagisawa, and
M Yamamoto, and
H Endo
June 1993,
Biological & pharmaceutical bulletin,
K Hirose, and
M Hakozaki, and
K Matsunaga, and
C Yoshikumi, and
T Hotta, and
M Yanagisawa, and
M Yamamoto, and
H Endo
May 1989,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
K Hirose, and
M Hakozaki, and
K Matsunaga, and
C Yoshikumi, and
T Hotta, and
M Yanagisawa, and
M Yamamoto, and
H Endo
September 1987,
Journal of clinical & laboratory immunology,
K Hirose, and
M Hakozaki, and
K Matsunaga, and
C Yoshikumi, and
T Hotta, and
M Yanagisawa, and
M Yamamoto, and
H Endo
March 2009,
Anticancer research,
