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The analgesic effect of clomipramine and the possible relationships between the antalgic action and the plasma levels of this tricyclic drug have been studied in 30 patients with chronic pain induced by nervous lesions determining a deafferentation. Twenty of 30 patients treated with clomipramine reported a significant improvement (up to 50%) observed as soon as the 4th day, with few side effects. The pharmacokinetic analysis shows the existence (r = 0.358; p less than 0.001) of a relationship between analgesia and plasma levels of clomipramine for each individual patient. This study also indicates a "therapeutic window" of plasma levels between 20 and 85 ng/ml. These results permit discussion of measurement of plasma levels of clomipramine in the treatment of chronic pain.
J L Montastruc, and
M A Tran, and
M Blanc, and
J P Charlet, and
J David, and
M Mansat, and
J Cotonat, and
M Patacq-Sapijanskas, and
B Guiraud-Chaumeil, and
A Rascol
February 1984,
Journal of affective disorders,
J L Montastruc, and
M A Tran, and
M Blanc, and
J P Charlet, and
J David, and
M Mansat, and
J Cotonat, and
M Patacq-Sapijanskas, and
B Guiraud-Chaumeil, and
A Rascol
June 1982,
Journal of affective disorders,
J L Montastruc, and
M A Tran, and
M Blanc, and
J P Charlet, and
J David, and
M Mansat, and
J Cotonat, and
M Patacq-Sapijanskas, and
B Guiraud-Chaumeil, and
A Rascol
January 1994,
Journal of geriatric psychiatry and neurology,
J L Montastruc, and
M A Tran, and
M Blanc, and
J P Charlet, and
J David, and
M Mansat, and
J Cotonat, and
M Patacq-Sapijanskas, and
B Guiraud-Chaumeil, and
A Rascol
April 1979,
The British journal of psychiatry : the journal of mental science,
J L Montastruc, and
M A Tran, and
M Blanc, and
J P Charlet, and
J David, and
M Mansat, and
J Cotonat, and
M Patacq-Sapijanskas, and
B Guiraud-Chaumeil, and
A Rascol
January 1979,
Communications in psychopharmacology,
J L Montastruc, and
M A Tran, and
M Blanc, and
J P Charlet, and
J David, and
M Mansat, and
J Cotonat, and
M Patacq-Sapijanskas, and
B Guiraud-Chaumeil, and
A Rascol
February 1983,
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris,
J L Montastruc, and
M A Tran, and
M Blanc, and
J P Charlet, and
J David, and
M Mansat, and
J Cotonat, and
M Patacq-Sapijanskas, and
B Guiraud-Chaumeil, and
A Rascol
January 1977,
Postgraduate medical journal,
J L Montastruc, and
M A Tran, and
M Blanc, and
J P Charlet, and
J David, and
M Mansat, and
J Cotonat, and
M Patacq-Sapijanskas, and
B Guiraud-Chaumeil, and
A Rascol
January 1980,
The Journal of international medical research,
J L Montastruc, and
M A Tran, and
M Blanc, and
J P Charlet, and
J David, and
M Mansat, and
J Cotonat, and
M Patacq-Sapijanskas, and
B Guiraud-Chaumeil, and
A Rascol
January 1979,
The International journal of neuroscience,
J L Montastruc, and
M A Tran, and
M Blanc, and
J P Charlet, and
J David, and
M Mansat, and
J Cotonat, and
M Patacq-Sapijanskas, and
B Guiraud-Chaumeil, and
A Rascol
September 2003,
Journal of pharmacological sciences,
