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N-Nitrosomethylaniline (NMA) was incubated with liver microsomes from female mice and rats. Both formaldehyde and nitrite formation were determined in the same incubation mixture under various experimental conditions. The animals were pretreated with phenobarbital (PB) or butylhydroxytoluene (BHT) in order to modify microsomal monooxygenase activities. Furthermore, various possibilities were tried to supply the microsomal system with reducing equivalents (NADPH-regenerating system, NADPH-regenerating system plus NADH or NADH alone). It can be deduced from these experiments that both enzymatic activities--oxidative demethylation and reductive denitrosation of NMA--do not proceed in a parallel manner. Thus both reactions are different from each other. They represent two separate pathways in nitrosamine metabolism.
K E Appel, and
C S Rühl, and
A G Hildebrandt
January 1988,
Journal of cancer research and clinical oncology,
K E Appel, and
C S Rühl, and
A G Hildebrandt
December 1955,
Biochimica et biophysica acta,
K E Appel, and
C S Rühl, and
A G Hildebrandt
December 1990,
Carcinogenesis,
K E Appel, and
C S Rühl, and
A G Hildebrandt
October 2016,
The Journal of organic chemistry,
K E Appel, and
C S Rühl, and
A G Hildebrandt
January 2012,
The journal of physical chemistry. B,
K E Appel, and
C S Rühl, and
A G Hildebrandt
January 1988,
Drug metabolism and disposition: the biological fate of chemicals,
K E Appel, and
C S Rühl, and
A G Hildebrandt
May 2006,
Chemical communications (Cambridge, England),
K E Appel, and
C S Rühl, and
A G Hildebrandt
February 1990,
Carcinogenesis,
K E Appel, and
C S Rühl, and
A G Hildebrandt
June 1996,
General physiology and biophysics,
K E Appel, and
C S Rühl, and
A G Hildebrandt
May 1990,
Biochemical pharmacology,
