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Plasma bupivacaine levels were measured in 47 women undergoing extradural Caesarean delivery. They were divided into four groups according to the following dose regimens using 0.5% bupivacaine. Group A were given a bolus of 20 ml with increment after 20 minutes. Groups B and C were given 10 ml initially with further increments if required at 10 minutes (group B) and 20 minutes (group C); Group D consisted of patients who had an extradural block extended for emergency Caesarean delivery. In the elective groups the highest and most rapidly achieved values were associated with group A and the lowest levels found in group C. The highest levels of all were found in the emergency group. The investigation indicates that slow controlled induction of extradural anaesthesia for Caesarean section greatly reduces the risk of local anaesthetic toxicity.
E M Thompson, and
C M Wilson, and
J Moore, and
E McClean
January 1988,
Anaesthesia,
E M Thompson, and
C M Wilson, and
J Moore, and
E McClean
February 1988,
British journal of anaesthesia,
E M Thompson, and
C M Wilson, and
J Moore, and
E McClean
December 1992,
British journal of anaesthesia,
E M Thompson, and
C M Wilson, and
J Moore, and
E McClean
May 1995,
British journal of anaesthesia,
E M Thompson, and
C M Wilson, and
J Moore, and
E McClean
March 1990,
British journal of anaesthesia,
E M Thompson, and
C M Wilson, and
J Moore, and
E McClean
November 1992,
Anaesthesia,
E M Thompson, and
C M Wilson, and
J Moore, and
E McClean
November 1992,
Anaesthesia,
E M Thompson, and
C M Wilson, and
J Moore, and
E McClean
August 1988,
British journal of anaesthesia,
E M Thompson, and
C M Wilson, and
J Moore, and
E McClean
May 1984,
British journal of anaesthesia,
E M Thompson, and
C M Wilson, and
J Moore, and
E McClean
January 1998,
British journal of anaesthesia,
