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Male Fischer 344 rats were given a single oral dose of approximately 1289 mg/kg (8.7 mmol/kg) of [14C]DPGME. After dosing, expired air, excreta, and tissues were analyzed for 14C activity, and metabolites in urine were isolated and identified. Approximately 60% of the administered 14C activity was excreted in urine, while 27% was eliminated as 14CO2 within 48 hr after dosing. DPGME, PGME, dipropylene glycol, propylene glycol, as well as sulfate and glucuronide conjugates of DPGME were identified in urine of animals given [14C]DPGME. Results of the study indicate that DPGME is metabolized via the same routes to the same general types of metabolites as previously identified for propylene glycol monomethyl ether (PGME).
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July 1989,
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R R Miller, and
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August 1984,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
R R Miller, and
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December 1981,
Toxicology and applied pharmacology,
R R Miller, and
E A Hermann, and
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February 1986,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
R R Miller, and
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April 1990,
Bulletin of environmental contamination and toxicology,
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June 1983,
Toxicology and applied pharmacology,
R R Miller, and
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January 1987,
Drug metabolism and disposition: the biological fate of chemicals,
R R Miller, and
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August 1984,
Environmental health perspectives,
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June 1990,
Toxicology,
