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Fischer 344 rats (10/sex/exposure concentration) and New Zealand White rabbits (7/sex/exposure concentration) were exposed to 0, 15, 50, or 200 ppm (0, 91, 303, or 1212 mg/m3) of dipropylene glycol monomethyl ether (DPGME) for 6 hr/day, 5 days/week for 13 weeks. Criteria of response included general observations, body weights, clinical chemistry, hematology, urinalyses (rats only), necropsy, organ weights, and histopathology. There were no effects attributed to exposure to DPGME at any exposure concentration in either male or female rats or rabbits. The highest concentration tested (200 ppm) was approximately 40% of a saturated DPGME atmosphere. Based on the low vapor pressure of DPGME, and results in this 13-week study, DPGME appears to have a low subchronic vapor inhalation toxicity hazard.
T D Landry, and
B L Yano
December 1985,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
T D Landry, and
B L Yano
July 1989,
Toxicology,
T D Landry, and
B L Yano
January 1983,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
T D Landry, and
B L Yano
December 1981,
Toxicology and applied pharmacology,
T D Landry, and
B L Yano
August 1985,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
T D Landry, and
B L Yano
August 1984,
Environmental health perspectives,
T D Landry, and
B L Yano
August 1984,
Environmental health perspectives,
T D Landry, and
B L Yano
April 1990,
Bulletin of environmental contamination and toxicology,
T D Landry, and
B L Yano
June 1983,
Toxicology and applied pharmacology,
T D Landry, and
B L Yano
January 2002,
Toxicologic pathology,
