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Mouse-liver microsomal mono-oxygenases metabolize isoprene to the corresponding mono-epoxides. The reaction was NADPH- and O2-dependent and was inhibited by CO, SKF525-A and metyrapone. 3,4-Epoxy-3-methyl-1-butene was the major metabolite of isoprene, and the kinetic constants (Km and Vmax) for this epoxidation were determined by analysing the corresponding diol by g.l.c. in incubations with microsomes from control or pretreated mice. 3,4-Epoxy-2-methyl-1-butene was a minor metabolite (approx. 20%). 3,4-Epoxy-2-methyl-1-butene was epoxidated further to the mutagenic isoprene dioxide by microsomes from control or pretreated mice. The Km and Vmax were determined and phenobarbital shown to be an inducer of this epoxidation.
M Del Monte, and
L Citti, and
P G Gervasi
March 1990,
Biochemical and biophysical research communications,
M Del Monte, and
L Citti, and
P G Gervasi
November 1979,
Biochemical pharmacology,
M Del Monte, and
L Citti, and
P G Gervasi
February 1979,
Biochemical Society transactions,
M Del Monte, and
L Citti, and
P G Gervasi
January 1993,
Vestnik Rossiiskoi akademii meditsinskikh nauk,
M Del Monte, and
L Citti, and
P G Gervasi
August 1982,
Xenobiotica; the fate of foreign compounds in biological systems,
M Del Monte, and
L Citti, and
P G Gervasi
January 1997,
Eksperimental'naia i klinicheskaia farmakologiia,
M Del Monte, and
L Citti, and
P G Gervasi
August 1979,
The Biochemical journal,
M Del Monte, and
L Citti, and
P G Gervasi
February 1980,
Biochemical pharmacology,
M Del Monte, and
L Citti, and
P G Gervasi
January 1988,
Annales francaises d'anesthesie et de reanimation,
M Del Monte, and
L Citti, and
P G Gervasi
October 1976,
Xenobiotica; the fate of foreign compounds in biological systems,
